RGD Reference Report - Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study. - Rat Genome Database

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Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study.

Authors: Terra Junior, Orlando Nascimento  Maldonado, Gabriel de Carvalho  Alfradique, Guilherme Rohem  Lisboa, Vinicius da Cunha  Arnóbio, Adriano  de Lima, Dirce Bonfim  Diamond, Hilda Rachel  de Souza, Maria Helena Faria Ornellas 
Citation: Terra Junior ON, etal., ScientificWorldJournal. 2016;2016:2085871. doi: 10.1155/2016/2085871. Epub 2016 Jun 13.
RGD ID: 40818276
Pubmed: PMID:27382604   (View Abstract at PubMed)
PMCID: PMC4921643   (View Article at PubMed Central)
DOI: DOI:10.1155/2016/2085871   (Journal Full-text)

The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NK(dim) and NK(bright)) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p = 0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p = 0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NCR1Humanacquired immunodeficiency syndrome  IEP protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
NCR3Humanacquired immunodeficiency syndrome  IEP protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr1Ratacquired immunodeficiency syndrome  ISONCR1 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr1Mouseacquired immunodeficiency syndrome  ISONCR1 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr3Ratacquired immunodeficiency syndrome  ISONCR3 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
Ncr3-psMouseacquired immunodeficiency syndrome  ISONCR3 (Homo sapiens)protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3  (natural cytotoxicity triggering receptor 3)

Genes (Mus musculus)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3-ps  (natural cytotoxicity triggering receptor 3, pseudogene)

Genes (Homo sapiens)
NCR1  (natural cytotoxicity triggering receptor 1)
NCR3  (natural cytotoxicity triggering receptor 3)


Additional Information