RGD Reference Report - Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. - Rat Genome Database

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Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.

Authors: Kohlhapp, Frederick J  Huelsmann, Erica J  Lacek, Andrew T  Schenkel, Jason M  Lusciks, Jevgenijs  Broucek, Joseph R  Goldufsky, Josef W  Hughes, Tasha  Zayas, Janet P  Dolubizno, Hubert  Sowell, Ryan T  Kühner, Regina  Burd, Sarah  Kubasiak, John C  Nabatiyan, Arman  Marshall, Sh'Rae  Bommareddy, Praveen K  Li, Shengguo  Newman, Jenna H  Monken, Claude E  Shafikhani, Sasha H  Marzo, Amanda L  Guevara-Patino, Jose A  Lasfar, Ahmed  Thomas, Paul G  Lattime, Edmund C  Kaufman, Howard L  Zloza, Andrew 
Citation: Kohlhapp FJ, etal., Cell Rep. 2016 Oct 18;17(4):957-965. doi: 10.1016/j.celrep.2016.09.068.
RGD ID: 40818261
Pubmed: PMID:27760326   (View Abstract at PubMed)
PMCID: PMC5589518   (View Article at PubMed Central)
DOI: DOI:10.1016/j.celrep.2016.09.068   (Journal Full-text)

In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1). Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PDCD1Humanmelanoma treatmentISOPdcd1 (Mus musculus)associated with influenzaRGD 
Pdcd1Ratmelanoma treatmentISOPdcd1 (Mus musculus)associated with influenzaRGD 
Pdcd1Mousemelanoma treatmentIMP associated with influenzaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdcd1  (programmed cell death 1)

Genes (Mus musculus)
Pdcd1  (programmed cell death 1)

Genes (Homo sapiens)
PDCD1  (programmed cell death 1)


Additional Information