RGD Reference Report - The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites. - Rat Genome Database

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The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites.

Authors: Bakr, May  Jullié, Damien  Krapivkina, Julia  Paget-Blanc, Vincent  Bouit, Lou  Petersen, Jennifer D  Retailleau, Natacha  Breillat, Christelle  Herzog, Etienne  Choquet, Daniel  Perrais, David 
Citation: Bakr M, etal., Cell Rep. 2021 Sep 7;36(10):109678. doi: 10.1016/j.celrep.2021.109678.
RGD ID: 405650337
Pubmed: PMID:34496238   (View Abstract at PubMed)
DOI: DOI:10.1016/j.celrep.2021.109678   (Journal Full-text)

The endosomal recycling system dynamically tunes synaptic strength, which underlies synaptic plasticity. Exocytosis is involved in the expression of long-term potentiation (LTP), as postsynaptic cleavage of the SNARE (soluble NSF-attachment protein receptor) protein VAMP2 by tetanus toxin blocks LTP. Moreover, induction of LTP increases the exocytosis of transferrin receptors (TfRs) and markers of recycling endosomes (REs), as well as post-synaptic AMPA type receptors (AMPARs). However, the interplay between AMPAR and TfR exocytosis remains unclear. Here, we identify VAMP4 as the vesicular SNARE that mediates most dendritic RE exocytosis. In contrast, VAMP2 plays a minor role in RE exocytosis. LTP induction increases the exocytosis of both VAMP2- and VAMP4-labeled organelles. Knock down (KD) of VAMP4 decreases TfR recycling but increases AMPAR recycling. Moreover, VAMP4 KD increases AMPAR-mediated synaptic transmission, which consequently occludes LTP expression. The opposing changes in AMPAR and TfR recycling upon VAMP4 KD reveal their sorting into separate endosomal populations.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Vamp4Ratglutamatergic synapse is_active_inIDA PMID:34496238SynGO 
Vamp4Ratglutamatergic synapse is_active_inIMP PMID:34496238SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Vamp4  (vesicle-associated membrane protein 4)


Additional Information