RGD Reference Report - Reduction of serotonin transporters of patients with chronic fatigue syndrome. - Rat Genome Database

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Reduction of serotonin transporters of patients with chronic fatigue syndrome.

Authors: Yamamoto, Shigeyuki  Ouchi, Yasuomi  Onoe, Hirotaka  Yoshikawa, Etsuji  Tsukada, Hideo  Takahashi, Hidetoshi  Iwase, Masao  Yamaguti, Kouzi  Kuratsune, Hirohiko  Watanabe, Yasuyoshi 
Citation: Yamamoto S, etal., Neuroreport. 2004 Dec 3;15(17):2571-4. doi: 10.1097/00001756-200412030-00002.
RGD ID: 38500210
Pubmed: PMID:15570154   (View Abstract at PubMed)
DOI: DOI:10.1097/00001756-200412030-00002   (Journal Full-text)

To assess the involvement of serotonin in the symptoms of chronic fatigue syndrome, we investigated the serotonergic neurotransmitter system of chronic fatigue syndrome patients by the positron emission tomography (PET). Here we show that the density of serotonin transporters (5-HTTs) in the brain, as determined by using a radiotracer, [C](+)McN5652, was significantly reduced in the rostral subdivision of the anterior cingulate as compared with that in normal volunteers. This subdivision is different from that in the dorsal anterior cingulate in which binding potential values of individual patient showed a weak negative correlation with self-reported pain score of the patients. Therefore, an alteration of serotonergic system in the rostral anterior cingulate plays a key role in pathophysiology of chronic fatigue syndrome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic fatigue syndrome  IEP 38500210protein:decreased expression:rostral anterior cingulate cortex (human)RGD 
chronic fatigue syndrome  ISOSLC6A4 (Homo sapiens)38500210; 38500210protein:decreased expression:rostral anterior cingulate cortex (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information