RGD Reference Report - MicroRNA-17 as a potential diagnostic biomarker in pulmonary arterial hypertension. - Rat Genome Database

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MicroRNA-17 as a potential diagnostic biomarker in pulmonary arterial hypertension.

Authors: Li, Haiwen  Yang, Zhiming  Gao, Fen  Zhang, Yueying  Meng, Weihao  Rong, Shuling 
Citation: Li H, etal., J Int Med Res. 2020 Jun;48(6):300060520920430. doi: 10.1177/0300060520920430.
RGD ID: 329349306
Pubmed: PMID:32600075   (View Abstract at PubMed)
PMCID: PMC7328490   (View Article at PubMed Central)
DOI: DOI:10.1177/0300060520920430   (Journal Full-text)


OBJECTIVE: This study aimed to detect circulating microRNA (miR)-17 and miR-20a levels in patients with pulmonary arterial hypertension (PAH), and to investigate whether circulating miR-17 levels are associated with PAH.
METHODS: Thirty-five PAH patients and 20 healthy controls were enrolled in the study. Circulating miR-17 and miR-20a levels were measured using real-time PCR analysis.
RESULTS: miR-17 levels were significantly increased in PAH patients compared with healthy controls. They were also higher in PAH patients at World Health Organization functional class (WHO FC) III-IV than WHO FC I-II PAH patients. There was no significant difference in miR-20a levels between PAH patients and controls. miR-17 had a high area under the corresponding receiver operating characteristic curve. Further, we found that circulating miR-17 levels correlated with the 6-minute walk distance, mean pulmonary artery pressure, and mean right atrial pressure in PAH patients.
CONCLUSION: Circulating miR-17 levels may be associated with human PAH. Therefore, miR-17 could be used as a diagnostic index and prognostic factor for PAH patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR17HumanPulmonary Arterial Hypertension severityIEP miRNA:increased expression:bloodRGD 
Mir17MousePulmonary Arterial Hypertension severityISOMIR17 (Homo sapiens)miRNA:increased expression:bloodRGD 
Mir17RatPulmonary Arterial Hypertension severityISOMIR17 (Homo sapiens)miRNA:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir17  (microRNA 17)

Genes (Mus musculus)
Mir17  (microRNA 17)

Genes (Homo sapiens)
MIR17  (microRNA 17)


Additional Information