RGD Reference Report - Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. - Rat Genome Database

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Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis.

Authors: Hassan, R  Laszik, ZG  Lerner, M  Raffeld, M  Postier, R  Brackett, D 
Citation: Hassan R, etal., Am J Clin Pathol. 2005 Dec;124(6):838-45.
RGD ID: 2326064
Pubmed: PMID:16416732   (View Abstract at PubMed)

Mesothelin, a cell surface glycoprotein present on normal mesothelial cells, has been reported to be expressed in pancreatic adenocarcinomas. We conducted this study to fully characterize mesothelin expression in surgically resected, formalin-fixed, paraffin-embedded tissue specimens of 18 pancreatic adenocarcinomas, 9 adenocarcinomas of the ampulla of Vater, 12 adenocarcinomas of the common bile duct, and 17 cases of chronic pancreatitis. Mesothelin immunostaining was performed using the antimesothelin monoclonal antibody 5B2. All 18 cases (100%) of pancreatic adenocarcinomas showed mesothelin expression, as did 8 (89%) of 9 cases of ampullar adenocarcinoma and all 12 cases (100%) of common bile duct adenocarcinoma. In all cases of pancreaticobiliary adenocarcinoma, the adjacent normal pancreas did not stain for mesothelin. Of 17 specimens of chronic pancreatitis, 16 were negative for mesothelin expression, and 1 case showed weak mesothelin staining of fewer than 5% of normal pancreatic ducts. Our results demonstrated mesothelin expression in the majority of pancreaticobiliary adenocarcinomas and no expression in normal pancreatic tissues and in chronic pancreatitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
common bile duct neoplasm  IEP 2326064protein:increased expression:common bile duct and ampulla of vaterRGD 
common bile duct neoplasm  ISOMSLN (Homo sapiens)2326064; 2326064protein:increased expression:common bile duct and ampulla of vaterRGD 

Objects Annotated

Genes (Rattus norvegicus)
Msln  (mesothelin)

Genes (Mus musculus)
Msln  (mesothelin)

Genes (Homo sapiens)
MSLN  (mesothelin)


Additional Information