RGD Reference Report - Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. - Rat Genome Database

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Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates.

Authors: Jhala, N  Jhala, D  Vickers, SM  Eltoum, I  Batra, SK  Manne, U  Eloubeidi, M  Jones, JJ  Grizzle, WE 
Citation: Jhala N, etal., Am J Clin Pathol. 2006 Oct;126(4):572-9.
RGD ID: 2326060
Pubmed: PMID:17019794   (View Abstract at PubMed)

This study was undertaken to determine whether recently identified proteins could be translated to clinical practice as markers to distinguish pancreatic adenocarcinoma from chronic pancreatitis on fine-needle aspirate (FNA) samples. Resected pancreatic tissue sections (n = 40) and FNA samples (n = 65) were stained for clusterin-beta, MUC4, survivin, and mesothelin. For each biomarker, the staining patterns in adenocarcinoma and in reactive ductal epithelium were evaluated and compared. Clusterin-beta stained reactive ductal epithelium significantly more frequently than pancreatic adenocarcinoma (P < .001). In comparison, MUC4 and mesothelin were expressed more frequently in pancreatic adenocarcinoma on tissue sections. Positive staining for MUC4 (91% vs 0%; P < .001) and mesothelin (62% vs 0%; P = .01) and absence of staining for clusterin-beta (90% vs 7%; P < .001) were noted significantly more frequently in adenocarcinoma cells than in reactive cells in FNA samples. Clusterin-beta and MUC4 can help distinguish reactive ductal epithelial cells from the cells of pancreatic adenocarcinoma in FNA samples.




  
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Term
Qualifier
Evidence
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Original Reference(s)
MSLNHumanpancreatic cancer  IEP associated with Pancreatic Disease; protein:increased expression:pancreasRGD 
MslnRatpancreatic cancer  ISORGD:1349818associated with Pancreatic Disease; protein:increased expression:pancreasRGD 
MslnMousepancreatic cancer  ISORGD:1349818associated with Pancreatic Disease; protein:increased expression:pancreasRGD 


Genes (Rattus norvegicus)
Msln  (mesothelin)

Genes (Mus musculus)
Msln  (mesothelin)

Genes (Homo sapiens)
MSLN  (mesothelin)