RGD Reference Report - Expression of hepatocyte growth factor, keratinocyte growth factor and their receptors in experimental chronic pancreatitis. - Rat Genome Database

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Expression of hepatocyte growth factor, keratinocyte growth factor and their receptors in experimental chronic pancreatitis.

Authors: Otte, JM  Schwenger, M  Brunke, G  Sparmann, G  Emmrich, J  Schmitz, F  Folsch, UR  Herzig, KH 
Citation: Otte JM, etal., Eur J Clin Invest. 2001 Oct;31(10):865-75.
RGD ID: 2317606
Pubmed: PMID:11737224   (View Abstract at PubMed)

BACKGROUND: Hepatocyte (HGF) and Keratinocyte growth factors (KGF) are key factors of tissue organization and regeneration. These peptide growth factors and their receptors c-met and keratinocyte growth factor receptor (KGFR) are overexpressed in pancreatic cancer. AIM: Expression and localization of ligands and receptors were investigated during the development of experimental chronic pancreatitis. METHODS: Chronic pancreatitis was induced in rats by intravenous injection of dibutyltin dichloride. One to 60 days after treatment, the expression of growth factors and receptors was analysed by competitive polymerase chain reaction, Western blot analysis and immunohistochemistry. RESULTS: HGF mRNA expression increased (10-fold) until days 7-14 followed by a decrease to control level. Expression of c-met mRNA constantly increased (15-fold). KGF and KGFR mRNA expression were increased after 14-28 days (5-fold) and then returned to control levels. mRNA expression patterns correlated with changes in the protein expression, whereas protein levels of KGF remained unchanged. Ligands were localized in mesenchymal cells and their receptors on epithelial cells. CONCLUSIONS: The significant increase of HGF and c-met expression suggests an essential role of this growth factor in the morphological changes during the development of chronic pancreatitis. Changes in the expression of KGF and KGFR are less pronounced.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
METHumanpancreatitis  ISOMet (Rattus norvegicus)mRNA:increased expression:pancreas (rat)RGD 
MetRatpancreatitis  IEP mRNA:increased expression:pancreas (rat)RGD 
MetMousepancreatitis  ISOMet (Rattus norvegicus)mRNA:increased expression:pancreas (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Met  (MET proto-oncogene, receptor tyrosine kinase)

Genes (Mus musculus)
Met  (met proto-oncogene)

Genes (Homo sapiens)
MET  (MET proto-oncogene, receptor tyrosine kinase)


Additional Information