RGD Reference Report - Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. - Rat Genome Database

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Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure.

Authors: Yndestad, A  Landro, L  Ueland, T  Dahl, CP  Flo, TH  Vinge, LE  Espevik, T  Froland, SS  Husberg, C  Christensen, G  Dickstein, K  Kjekshus, J  Oie, E  Gullestad, L  Aukrust, P 
Citation: Yndestad A, etal., Eur Heart J. 2009 May;30(10):1229-36. Epub 2009 Mar 26.
RGD ID: 2316495
Pubmed: PMID:19329498   (View Abstract at PubMed)
DOI: DOI:10.1093/eurheartj/ehp088   (Journal Full-text)

AIMS: Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of NGAL in heart failure (HF). METHODS AND RESULTS: Our main findings were (i) patients with acute post-myocardial infarction (MI) HF (n = 236) and chronic HF (n = 150) had elevated serum levels of NGAL (determined by enzyme immunoassay), significantly correlated with clinical and neurohormonal deterioration, (ii) in patients with HF following acute MI, elevated NGAL levels of at baseline were associated with adverse outcomes (median of 27 months follow-up), (iii) in a rat model of post-MI HF, NGAL/lipocalin-2 gene expression was increased in the non-ischaemic part of the left ventricle primarily located to cardiomyocytes, (iv) strong NGAL immunostaining was found in cardiomyocytes within the failing myocardium both in experimental and clinical HF, (v) interleukin-1beta and agonists for toll-like receptors 2 and 4, representing components of the innate immune system, were potent inducers of NGAL/lipocalin-2 in isolated neonatal cardiomyocytes. CONCLUSION: Our demonstration of enhanced systemic and myocardial NGAL expression in clinical and experimental HF further support a role for innate immune responses in the pathogenesis of HF.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Lcn2Ratcellular response to interleukin-1  IEP IL-1betaRGD 
Lcn2Ratcellular response to lipopolysaccharide  IEP  RGD 
Lcn2Ratcellular response to tumor necrosis factor  IEP TNFalphaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Lcn2  (lipocalin 2)


Additional Information