RGD Reference Report - Ethanol modulates GABA(B) receptor expression in cortex and hippocampus of the adult rat brain. - Rat Genome Database

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Ethanol modulates GABA(B) receptor expression in cortex and hippocampus of the adult rat brain.

Authors: Li, SP  Park, MS  Jin, GZ  Kim, JH  Lee, HL  Lee, YL  Kim, JH  Bahk, JY  Park, TJ  Koh, PO  Chung, BC  Kim, MO 
Citation: Li SP, etal., Brain Res. 2005 Nov 2;1061(1):27-35. Epub 2005 Oct 24.
RGD ID: 2315490
Pubmed: PMID:16246313   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2005.08.052   (Journal Full-text)

Using in situ hybridization, RNase protection assay and Western blot, we studied the effects of ethanol on the expression levels of GABA(B) receptor mRNA and protein in the cortex and hippocampus from adult rat brain. The results showed that ethanol significantly increased GABA(B1) and GABA(B2) receptor protein expression in the cortex, whereas only GABA(B2) was increased in the hippocampus. GABA(B) receptor agonist baclofen could partially reverse the effect of ethanol. Further studies of the mRNA levels defined that GABA(B1) mRNA levels were significantly increased in the hippocampus, with no significant changes of GABA(B2) mRNA levels. Moreover, GABA(B1) and GABA(B2) receptor mRNA levels were increased on 3-week ethanol treatment. Finally, GABA(B) agonist baclofen and antagonist phaclofen showed significant decreasing effects on GABA(B1) receptor mRNA levels in the cortex, but not in the hippocampus. These results were further confirmed by in situ hybridization. Thus, the present results showed the effects of ethanol on GABA(B) receptors in the cortex and hippocampus, implying the possible role of GABA(B) receptor in ethanol effects. The effects of GABA(B) receptor agonist and antagonist suggested that the possible mechanisms underlying that GABA(B) receptor modulated the behavioral effect induced by ethanol.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gabbr1Ratresponse to ethanol  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)


Additional Information