RGD Reference Report - The biochemical study of rat T-cell growth factor (interleukin 2). - Rat Genome Database

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The biochemical study of rat T-cell growth factor (interleukin 2).

Authors: Nesmeyanov, VA  Valyakina, TI  Alexenko, AP  Lavrova, NV  Lakhtina, OE  Chikirdina, EE  Kulshin, VA 
Citation: Nesmeyanov VA, etal., Immunol Lett. 1984;7(5):273-7.
RGD ID: 2303494
Pubmed: PMID:6609879   (View Abstract at PubMed)

T-cell growth factor (interleukin 2) was partially purified from the conditioned medium from Con A-stimulated rat splenocytes. It had the molecular weight of 23,000 according to gel filtration and in the range of 17,000-18,000 daltons according to PAGE in the presence of SDS. The molecular forms of IL 2 exhibited isoelectric points (pI) of 5.4-5.8 (major peak), 4.3-4.5 and 6.5-6.8 (minor peaks). T-cell growth-promoting activity was remarkably stable to temperature, pH, SDS and 2-ME treatments. Rat IL 2 did not bind to immobilized Con A, WGA, RC 1, and fucose-binding protein. The conditioned medium also contained the inhibitor of IL 2-dependent T-cell proliferation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il2Ratpositive regulation of T cell proliferation  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il2  (interleukin 2)


Additional Information