RGD Reference Report - Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes. - Rat Genome Database

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Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes.

Authors: Yamasaki, M  Hasegawa, S  Suzuki, H  Hidai, K  Saitoh, Y  Fukui, T 
Citation: Yamasaki M, etal., Biochem Biophys Res Commun. 2005 Sep 16;335(1):215-9.
RGD ID: 2301021
Pubmed: PMID:16055091   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2005.07.053   (Journal Full-text)

Acetoacetyl-CoA synthetase (AACS, acetoacetate-CoA ligase, EC 6.2.1.16) is a novel cytosolic ketone body (acetoacetate)-specific ligase, the physiological role of which remains to be elucidated. We examined the expression profiles of AACS mRNA in adult rat tissues, finding that it was particularly abundant in male subcutaneous white adipose tissue after weaning. In white adipose tissue, AACS mRNA was preferentially detected in mature adipocytes but not in preadipocytes. The AACS mRNA expression in primary preadipocytes increased during the adipocyte differentiation. These expression profiles were similar to that of acetyl-CoA carboxylase-1, but not like to that of 3-hydroxy-3-methylglutaryl-CoA reductase. These results suggest that AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
AacsRatadipose tissue development  IEP  RGD 
AacsRatwhite fat cell differentiation  IEP  RGD 


Genes (Rattus norvegicus)
Aacs  (acetoacetyl-CoA synthetase)