RGD Reference Report - Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis. - Rat Genome Database

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Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis.

Authors: McCarthy, JB  Milner, TA 
Citation: McCarthy JB and Milner TA, Neuroreport. 2003 Jul 18;14(10):1357-60.
RGD ID: 2299084
Pubmed: PMID:12876473   (View Abstract at PubMed)
DOI: DOI:10.1097/01.wnr.0000078380.40088.99   (Journal Full-text)

Synapse number and dendritic spine number fluctuate across the estrous cycle in the hippocampal CA1 stratum radiatum. The synaptogenesis phase of estrous is driven by estrogen and may require newly synthesized proteins. Ribosomes synthesize soluble proteins when free in the cytoplasm, and integral membrane or secretory proteins when membrane-associated. Here we report that ribosomal immunoreactivity and the percentage associated with membranes increases locally in dendrites of the CA1 stratum radiatum during estrogen-induced synaptogenesis. These findings are consistent with a role for estrogen in regulating the local synthesis of integral membrane proteins, e.g. receptors, in dendrites for newly developing synapses across the estrous cycle.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Rps3Rattranslation  ICGO:0012505membrane and/or secretory protein synthesisRGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Rps3Ratcytosolic small ribosomal subunit  IDA  RGD 
Rps3Ratdendrite  IDA  RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Rps3Ratstructural constituent of ribosome  ICGO:0022627 RGD 


Genes (Rattus norvegicus)
Rps3  (ribosomal protein S3)