RGD Reference Report - Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.

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Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.
Authors:	Liu, W Chang, BL Cramer, S Koty, PP Li, T Sun, J Turner, AR Von Kap-Herr, C Bobby, P Rao, J Zheng, SL Isaacs, WB Xu, J
Citation:	Liu W, etal., Clin Cancer Res. 2007 Sep 1;13(17):5028-33.
RGD ID:	2298803
Pubmed:	PMID:17785553 (View Abstract at PubMed)
DOI:	DOI:10.1158/1078-0432.CCR-07-0300 (Journal Full-text)
PURPOSE: Chromosome 6q14-21 is commonly deleted in prostate cancers, occurring in approximately 22% of all tumors and approximately 40% of metastatic tumors. However, candidate prostate tumor suppressor genes in this region have not been identified, in part due to the large and broad nature of the deleted region implicated in previous studies. EXPERIMENTAL DESIGN: We first used high-resolution Affymetrix single nucleotide polymorphism arrays to examine DNA from malignant and matched nonmalignant cells from 55 prostate cancer patients. We identified a small consensus region on 6q14-21 and evaluated the deletion status within the region among additional 40 tumors and normal pairs using quantitative PCR and fluorescence in situ hybridization. We finally tested the association between the deletion and Gleason score using the Fisher's exact test. RESULTS: Tumors with small, interstitial deletions at 6q14-21 defined an 817-kb consensus region that is affected in 20 of 21 tumors. The MAP3K7 gene is one of five genes located in this region. In total, MAP3K7 was deleted in 32% of 95 tumors. Importantly, deletion of MAP3K7 was highly associated with higher-grade disease, occurring in 61% of tumors with Gleason score >or=8 compared with only 22% of tumors with Gleason score

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
MAP3K7	Human	prostate cancer		IAGP		DNA:deletion	RGD
Map3k7	Rat	prostate cancer		ISO	MAP3K7 (Homo sapiens)		RGD
Map3k7	Mouse	prostate cancer		ISO	MAP3K7 (Homo sapiens)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Map3k7 (mitogen activated protein kinase kinase kinase 7)

Genes (Mus musculus)

Map3k7 (mitogen-activated protein kinase kinase kinase 7)

Genes (Homo sapiens)

MAP3K7 (mitogen-activated protein kinase kinase kinase 7)

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Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.