RGD Reference Report - Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer. - Rat Genome Database

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Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer.

Authors: Lim, SL  Smith, P  Syed, N  Coens, C  Wong, H  Van der Burg, M  Szlosarek, P  Crook, T  Green, JA 
Citation: Lim SL, etal., Br J Cancer. 2008 Apr 22;98(8):1452-6. Epub 2008 Apr 15.
RGD ID: 2298507
Pubmed: PMID:18414472   (View Abstract at PubMed)
PMCID: PMC2361708   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjc.6604325   (Journal Full-text)

The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methylation-sensitive polymerase chain reaction of FANCF in nine ovarian cancer cell lines and 74 ovarian cancer samples taken from patients entered on a trial of cisplatin-based chemotherapy. This study confirmed methylation-dependent silencing of FANCF in one out of nine ovarian cancer cell lines. Methylation of FANCF was demonstrated in 13.2% of 53 evaluable ovarian tumour samples. Progression-free survival gave an HR of 3.63 (95% CI: 1.54-8.54, P=0.0016) in favour of the unmethylated cases. There was no association with overall survival. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FANCFHumanOvarian Neoplasms disease_progressionIDA DNA:hypermethylation:promoterRGD 
FancfRatOvarian Neoplasms disease_progressionISOFANCF (Homo sapiens)DNA:hypermethylation:promoterRGD 
FancfMouseOvarian Neoplasms disease_progressionISOFANCF (Homo sapiens)DNA:hypermethylation:promoterRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fancf  (FA complementation group F)

Genes (Mus musculus)
Fancf  (Fanconi anemia, complementation group F)

Genes (Homo sapiens)
FANCF  (FA complementation group F)


Additional Information