RGD Reference Report - Effect of Ca(2+) and Mg(2+) on the Mn-superoxide dismutase from rat liver and heart mitochondria. - Rat Genome Database

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Effect of Ca(2+) and Mg(2+) on the Mn-superoxide dismutase from rat liver and heart mitochondria.

Authors: Perez-Vazquez, V  Ramirez, J  Aguilera-Aguirre, L  Gonzalez-Hernandez, JC  Clemente-Guerrero, M  Manzo-Avalos, S  Uribe, S  Saavedra-Molina, A 
Citation: Perez-Vazquez V, etal., Amino Acids. 2002 Jun;22(4):405-16.
RGD ID: 2291939
Pubmed: PMID:12107766   (View Abstract at PubMed)
DOI: DOI:10.1007/s007260200024   (Journal Full-text)

The manganese superoxide dismutase (Mn-SOD) converts superoxide anions to hydrogen peroxide plus oxygen, providing the first line of defense against oxidative stress in mitochondria. Heart mitochondria exhibited higher Mn-SOD activity than liver mitochondria. In mitochondria from both tissues Mn-SOD activity decreased after incubation at low oxygen concentration (hypoxic mitochondria). The effects of free Ca(2+) ([Ca(2+)](f)) and free Mg(2+) ([Mg(2+)](f)) on normoxic and hypoxic mitochondria from either organ were tested. In normoxic mitochondria from either tissue, both [Ca(2+)](f) and [Mg(2+)](f) activated the enzyme, although [Mg(2+)](f) was less efficient as an activator and the effect was lower in heart than in liver mitochondria. When added simultaneously, high [Ca(2+)](f) and [Mg(2+)](f) exhibited additive effects which were more pronounced in heart mitochondria and were observed regardless of whether mitochondria had been incubated under normal or low oxygen. The data suggest that [Ca(2+)](f) plays a role in regulating Mn-SOD in concert with the activation of aerobic metabolism.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Sod2Ratremoval of superoxide radicals  IDA  RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Sod2Ratoxygen binding  IDA  RGD 
Sod2Ratsuperoxide dismutase activity  IDA  RGD 


Genes (Rattus norvegicus)
Sod2  (superoxide dismutase 2)