RGD Reference Report - E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. - Rat Genome Database

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E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia.

Authors: Brooks, LA  Sullivan, A  O'Nions, J  Bell, A  Dunne, B  Tidy, JA  Evans, DJ  Osin, P  Vousden, KH  Gusterson, B  Farrell, PJ  Storey, A  Gasco, M  Sakai, T  Crook, T 
Citation: Brooks LA, etal., Br J Cancer. 2002 Jan 21;86(2):263-8.
RGD ID: 2290589
Pubmed: PMID:11870517   (View Abstract at PubMed)
PMCID: PMC2375198   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjc.6600033   (Journal Full-text)

In common with other E2F1 responsive genes such as p14(ARF) and B-myb, the promoter of p73 is shown to be positively regulated in cell lines and primary human keratinocytes by E7 proteins from oncogenic human papillomavirus (HPV) types 16, 18, 31 and 33, but not HPV 6. Mutational analysis revealed that transactivation of the p73 promoter by HPV 16E7 requires association with pRb. Expression of p73 in normal cervical epithelium is confined to the basal and supra-basal layers. In contrast, expression in neoplastic lesions is detected throughout the epithelium and increases with grade of neoplasia, being maximal in squamous cell cancers (SCC). Deregulation of expression of the N-terminal splice variant p73Delta2 was observed in a significant proportion of cancers, but not in normal epithelium. The frequent over-expression of p73Delta2, which has recognized transdominant properties, in malignant and pre-malignant lesions suggests a role in the oncogenic process in cervical epithelium.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP73Humancervix uteri carcinoma in situ disease_progressionIEP mRNA:increased expression:uterine cervixRGD 
Tp73Ratcervix uteri carcinoma in situ disease_progressionISOTP73 (Homo sapiens)mRNA:increased expression:uterine cervixRGD 
Trp73Mousecervix uteri carcinoma in situ disease_progressionISOTP73 (Homo sapiens)mRNA:increased expression:uterine cervixRGD 
TP73HumanUterine Cervical Neoplasms  IEP mRNA more ...RGD 
Tp73RatUterine Cervical Neoplasms  ISOTP73 (Homo sapiens)mRNA more ...RGD 
Trp73MouseUterine Cervical Neoplasms  ISOTP73 (Homo sapiens)mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
TP73  (tumor protein p73)


Additional Information