RGD Reference Report - Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor. - Rat Genome Database

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Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor.

Authors: Magby, JP  Bi, C  Chen, ZY  Lee, FS  Plummer, MR 
Citation: Magby JP, etal., J Neurosci. 2006 Dec 27;26(52):13531-6.
RGD ID: 1600576
Pubmed: PMID:17192436   (View Abstract at PubMed)
PMCID: PMC6674723   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4576-06.2006   (Journal Full-text)

Brain-derived neurotrophic factor (BDNF) is a key regulator of hippocampal synaptic plasticity in the developing and adult nervous system. It can be released from pyramidal neuron dendrites in an activity-dependent manner and has therefore been suggested to serve as a signal that provides the retrograde intercellular communication necessary for Hebbian plasticity and hippocampal-dependent learning. Although much has been learned about BDNF function by field stimulation of hippocampal neurons, it is not known whether moderate action potential-independent depolarization of single cells is capable of releasing sufficient BDNF to influence transmission at individual synapses. In this study, we show directly at the single-cell level that such modulation can occur. By using K-252a, anti-BDNF antibody, and interruption of regulated release, we confirm a model in which postsynaptic depolarization elicits calcium-dependent release of BDNF that diffuses retrogradely and enhances presynaptic transmitter release.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
BdnfRatexcitatory postsynaptic potential  IMP  RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
BdnfRatsynaptic vesicle  IDA  RGD 


Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)