RGD Reference Report - Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines. - Rat Genome Database

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Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines.

Authors: Imbert, V  Renauld, PR 
Citation: Imbert V and Renauld PR, Eur Cytokine Netw. 1999 Mar;10(1):71-8.
RGD ID: 1600126
Pubmed: PMID:10210776   (View Abstract at PubMed)

Cytokines and growth factors regulate expression of their target genes via the Janus kinase (Jak)/signal transducers and activators of transcription (STAT) signaling pathway. One of the best characterized targets of STAT is the interleukin-2 receptor-alpha (IL-2Ralpha) gene. Its transcription is controlled by interleukin 2 (IL-2) through STAT5 activation. Using the PC60 cell line, in which the role of STAT5 in the regulation of the murine IL-2Ralpha gene by IL-2 has been elucidated, we have compared the response of this gene to IL-2, interleukin-9 (IL-9) and erythropoietin (Epo). IL-2 and IL-9, but not Epo, stimulate cell surface expression of IL-2Ralpha. This correlates with the fact that IL-2 and IL-9 support long-term STAT5 activation whereas Epo only induces transient activation. In cells treated with vanadate, a protein tyrosine phosphatase (PTP) inhibitor, Epo induces prolonged STAT5 activation and strongly stimulates IL-2Ralpha expression. Our study suggests that by controlling the duration of the STAT activation signal, PTP influences the specificity of cytokine signaling.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il2raRatcell surface  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il2ra  (interleukin 2 receptor subunit alpha)


Additional Information