RGD Reference Report - Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. - Rat Genome Database

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Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.

Authors: Park, WS  Dong, SM  Kim, SY  Na, EY  Shin, MS  Pi, JH  Kim, BJ  Bae, JH  Hong, YK  Lee, KS  Lee, SH  Yoo, NJ  Jang, JJ  Pack, S  Zhuang, Z  Schmidt, L  Zbar, B  Lee, JY 
Citation: Park WS, etal., Cancer Res. 1999 Jan 15;59(2):307-10.
RGD ID: 1600123
Pubmed: PMID:9927037   (View Abstract at PubMed)

The MET protooncogene encodes a transmembrane tyrosine kinase identified as the receptor of a polypeptide known as hepatocyte growth factor/scatter factor. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the tyrosine kinase domain of the MET gene (exon 15-19) in 75 primary liver cancers. Three missense mutations were detected exclusively in 10 childhood hepatocellular carcinomas (HCCs), while no mutations were detected in 16 adult HCCs, 21 cholangiocarcinomas, or 28 hepatoblastomas. The extremely short incubation period from hepatitis B virus infection to the genesis of childhood HCC as compared with the adult HCC suggests that there may be an additional mechanism that accelerates the carcinogenesis of childhood HCC. Our results indicate that mutations of the tyrosine kinase domain of the MET gene may be involved in the acceleration of the carcinogenesis in childhood HCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
METHumanhepatocellular carcinoma  IAGP  RGD 
MetRathepatocellular carcinoma  ISOMET (Homo sapiens) RGD 
MetMousehepatocellular carcinoma  ISOMET (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Met  (MET proto-oncogene, receptor tyrosine kinase)

Genes (Mus musculus)
Met  (met proto-oncogene)

Genes (Homo sapiens)
MET  (MET proto-oncogene, receptor tyrosine kinase)


Additional Information