RGD Reference Report - Binding of interleukin 2 to gangliosides. - Rat Genome Database

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Binding of interleukin 2 to gangliosides.

Authors: Parker, J  Caldini, G  Krishnamurti, C  Ahrens, PB  Ankel, H 
Citation: Parker J, etal., FEBS Lett. 1984 May 21;170(2):391-5.
RGD ID: 1600093
Pubmed: PMID:6609839   (View Abstract at PubMed)

Exogenous gangliosides inhibit interleukin 2 (IL2)-dependent growth of a T cell line, AKIL -1.E8. IL2 activity is retained by columns of ganglioside covalently linked to poly(L-lysine)-agarose and is not eluted with ethylene glycol but is completely recovered by elution with 1% SDS. The ability of gangliosides to inhibit IL2 activity is directly related to the complexity of their carbohydrate portion, and related ceramide derivatives at similar concentrations do not inhibit IL2 activity. We conclude that IL2 bound to exogenous gangliosides is inactive and that the carbohydrate portion of the ganglioside is crucial to its interaction with IL2.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Il2Ratpositive regulation of T cell proliferation  IDA  RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Il2Ratcarbohydrate binding  IDA binds gangliosides GM1 more ...RGD 
Il2Ratglycosphingolipid binding  IDA binds gangliosides GM1 more ...RGD 


Genes (Rattus norvegicus)
Il2  (interleukin 2)