RGD Reference Report - Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. - Rat Genome Database

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Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.

Authors: McFarland, KC  Sprengel, R  Phillips, HS  Kohler, M  Rosemblit, N  Nikolics, K  Segaloff, DL  Seeburg, PH 
Citation: McFarland KC, etal., Science. 1989 Aug 4;245(4917):494-9.
RGD ID: 1566529
Pubmed: PMID:2502842   (View Abstract at PubMed)

A complementary DNA (cDNA) for the rat luteal lutropin-choriogonadotropin receptor (LH-CG-R) was isolated with the use of a DNA probe generated in a polymerase chain reaction with oligonucleotide primers based on peptide sequences of purified receptor protein. As would be predicted from the cDNA sequence, the LH-CG-R consists of a 26-residue signal peptide, a 341-residue extracellular domain displaying an internal repeat structure characteristic of members of the leucine-rich glycoprotein (LRG) family, and a 333-residue region containing seven transmembrane segments. This membrane-spanning region displays sequence similarity with all members of the G protein-coupled receptor family. Hence, the LH-CG-R gene may have evolved by recombination of LRG and G protein-coupled receptor genes. Cells engineered to express LH-CG-R cDNA bind human choriogonadotropin with high affinity and show an increase in cyclic adenosine monophosphate when exposed to hormone. As revealed by RNA blot analysis and in situ hybridization, the 4.4-kilobase cognate messenger RNA is prominently localized in the rat ovary.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LhcgrRatadenylate cyclase-modulating G protein-coupled receptor signaling pathway  IDA  RGD 
LhcgrRathormone-mediated signaling pathway  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LhcgrRatG protein-coupled peptide receptor activity  IDA  RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LHCGRHumanpeptide and protein hormone signaling pathway  ISOLhcgr (Rattus norvegicus)luteinizing hormone/chorionic gonadotropinRGD 
LhcgrRatpeptide and protein hormone signaling pathway  IDA luteinizing hormone/chorionic gonadotropinRGD 
LhcgrMousepeptide and protein hormone signaling pathway  ISOLhcgr (Rattus norvegicus)luteinizing hormone/chorionic gonadotropinRGD 
Objects Annotated

Genes (Rattus norvegicus)
Lhcgr  (luteinizing hormone/choriogonadotropin receptor)

Genes (Mus musculus)
Lhcgr  (luteinizing hormone/choriogonadotropin receptor)

Genes (Homo sapiens)
LHCGR  (luteinizing hormone/choriogonadotropin receptor)


Additional Information