RGD Reference Report - OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. - Rat Genome Database

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OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.

Authors: Kondo, S  Murakami, T  Tatsumi, K  Ogata, M  Kanemoto, S  Otori, K  Iseki, K  Wanaka, A  Imaizumi, K 
Citation: Kondo S, etal., Nat Cell Biol 2005 Feb;7(2):186-94. Epub 2005 Jan 23.
RGD ID: 1558627
Pubmed: PMID:15665855   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb1213   (Journal Full-text)

Endoplasmic reticulum (ER) stress transducers IRE1, PERK and ATF6 are well known to transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. Here, we identified OASIS as a novel ER stress transducer. OASIS is a basic leucine zipper (bZIP) transcription factor of the CREB/ATF family with a transmembrane domain that allows it to associate with the ER. The molecule is cleaved at the membrane in response to ER stress, and its cleaved amino-terminal cytoplasmic domain, which contains the bZIP domain, translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements. Intriguingly, OASIS was induced at the transcriptional level during ER stress in astrocytes of the central nervous system, but not in other cell types examined. Furthermore, overexpression of OASIS resulted in induction of BiP and suppression of ER-stress-induced cell death, whereas knockdown partially reduced BiP levels and led to ER stress in susceptible astrocytes. Our results reveal pivotal roles for OASIS in modulating the unfolded protein response in astrocytes, and the possibility that cell type-specific UPR signalling also exists in other cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Creb3l1Ratnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway involved_inIMP PMID:15665855ParkinsonsUK-UCL 
Creb3l1Ratpositive regulation of transcription by RNA polymerase II involved_inIMP PMID:15665855ParkinsonsUK-UCL 
Creb3l1Ratresponse to endoplasmic reticulum stress involved_inIMP PMID:15665855ParkinsonsUK-UCL 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Creb3l1Rattranscription cis-regulatory region binding enablesIDA PMID:15665855ParkinsonsUK-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Creb3l1  (cAMP responsive element binding protein 3-like 1)


Additional Information