RGD Reference Report - Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. - Rat Genome Database

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Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart.

Authors: Segat, D  Frie, C  Nitsche, PD  Klatt, AR  Piecha, D  Korpos, E  Deak, F  Wagener, R  Paulsson, M  Smyth, N 
Citation: Segat D, etal., Matrix Biol 2000 Dec;19(7):649-55.
RGD ID: 1556811
Pubmed: PMID:11102754   (View Abstract at PubMed)

The expression of matrilin-1, -2 and -3 was studied in the heart and limb during mouse development. Matrilin-1 is transiently expressed in the heart between days 9.5 and 14.5 p.c. Matrilin-2 expression was detected in the heart from day 10.5 p.c. onwards. In the developing limb bud, both matrilin-1 and -3 were observed first at day 12.5 p.c. Throughout development matrilin-3 expression was strictly limited to cartilage, while matrilin-1 was also found in some other forms of connective tissue. Matrilin-2, albeit present around hypertrophic chondrocytes in the growth plate, was mainly expressed in non-skeletal structures. The complementary, but in part overlapping, expression of matrilins indicates the possibility for both redundant and unique functions among the members of this novel family of extracellular matrix proteins.

Objects referenced in this article
Gene Matn1 matrilin 1, cartilage matrix protein Mus musculus
Gene Matn2 matrilin 2 Mus musculus
Gene Matn3 matrilin 3 Mus musculus

Additional Information