RGD Reference Report - Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis. - Rat Genome Database

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Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis.

Authors: Gong, Yanqiu  Pu, Wenchen  Jin, Hongyu  Yang, Pei  Zeng, Hao  Wang, Yuqi  Pang, Fuwen  Ma, Xuelei 
Citation: Gong Y, etal., Life Sci. 2018 Apr 1;198:94-98. doi: 10.1016/j.lfs.2018.02.035. Epub 2018 Feb 26.
RGD ID: 151708712
Pubmed: PMID:29496492   (View Abstract at PubMed)
DOI: DOI:10.1016/j.lfs.2018.02.035   (Journal Full-text)


AIM: Extranodal natural killer cell/T-cell lymphoma of nasal-type (NKTCL) is an aggressive human lymphoma, but its predicted biomarkers after chemotherapy are less known. The aim of this study is to find some potential predicted biomarkers in cerebrospinal fluid (CSF) of NKTCL patients with ethmoidal sinus metastasis (NESM).
MATERIALS AND METHODS: The CSF samples were obtained from NKTCL patients with NESM before and after chemotherapy from Cancer Center of West China Hospital. Comparative proteomic profiling using label-free method was performed to characterize the fold change of proteins in NESM patients.
KEY FINDING: In this study, 102 proteins with <1% false discovery rate in CSF of NKTCL with NESM patients were quantified. Furthermore, significantly reduced IGFBP2, SERP1NC1, AMBP and GPX3, as well as dramatically increased CPE levels were observed in the CSF of NKTCL patients after cytarabine chemotherapy.
SIGNIFICANCE: IGFBP2, SERP1NC1, AMBP, GPX3 and CPE together or alone have a potential to be predicted indicators of NKTCL with NESM in response to chemotherapy.




  
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Term
Qualifier
Evidence
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Original Reference(s)
GPX3Humannasal type extranodal NK/T-cell lymphoma treatmentIEP associated with ethmoid sinus cancer and Neoplasm MetastasisRGD 
Gpx3Ratnasal type extranodal NK/T-cell lymphoma treatmentISOGPX3 (Homo sapiens)associated with ethmoid sinus cancer and Neoplasm MetastasisRGD 
Gpx3Mousenasal type extranodal NK/T-cell lymphoma treatmentISOGPX3 (Homo sapiens)associated with ethmoid sinus cancer and Neoplasm MetastasisRGD 


Genes (Rattus norvegicus)
Gpx3  (glutathione peroxidase 3)

Genes (Mus musculus)
Gpx3  (glutathione peroxidase 3)

Genes (Homo sapiens)
GPX3  (glutathione peroxidase 3)