RGD Reference Report - [Expression and significance of gene Rad52 in nasopharyngeal carcinoma]. - Rat Genome Database

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[Expression and significance of gene Rad52 in nasopharyngeal carcinoma].

Authors: Wei, Lili  Yang, Xiaoli  Ming, Huixin  Li, Ping 
Citation: Wei L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Apr;28(7):486-9.
RGD ID: 151361208
Pubmed: PMID:25026830   (View Abstract at PubMed)


OBJECTIVE: To investigate the expression and clinical significance of Rad52, a homologous recombination repair gene, in tissues of nasopharyngeal carcinoma (NPC).
METHOD: The expression of Rad52 was detected with three-step immunohistochemistry technique in tissues of 38 NPC patients and which have the corresponding paracancerous tissues. All of the Rad52 expression and clinical data (gender, age, clinical stage ) were compared and analyzed to conclude the relationship between them.
RESULT: The Rad52 expressions were significantly different from NPC tissues to peri-NPC tissues (P < 0.05). It was found by Spearman analysis method that the Rad52 expression decreased with patients'clinical stages (P < 0.05), but has no significant relationship with gender, age, recurrence, and lymphonode metastasis (P > 0.05). The expression of Rad52 influenced the survival time of NPC patients significantly (P < 0.05).
CONCLUSION: The Rad52 expression can be a useful prognostic and treatment factor for NPC patients.




  
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Species
Term
Qualifier
Evidence
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Source
Original Reference(s)
RAD52Humannasopharynx carcinoma severityIEP protein:increased expression:nasopharynx (human)RGD 
Rad52Ratnasopharynx carcinoma severityISORAD52 (Homo sapiens)protein:increased expression:nasopharynx (human)RGD 
Rad52Mousenasopharynx carcinoma severityISORAD52 (Homo sapiens)protein:increased expression:nasopharynx (human)RGD 


Genes (Rattus norvegicus)
Rad52  (RAD52 homolog, DNA repair protein)

Genes (Mus musculus)
Rad52  (RAD52 homolog, DNA repair protein)

Genes (Homo sapiens)
RAD52  (RAD52 homolog, DNA repair protein)