RGD Reference Report - A20 enhances the radiosensitivity of hepatocellular carcinoma cells to 60Co-γ ionizing radiation. - Rat Genome Database

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A20 enhances the radiosensitivity of hepatocellular carcinoma cells to 60Co-γ ionizing radiation.

Authors: Liu, Rui  Zhao, Dongli  Zhang, Xiaozhi  Han, Suxia  Yang, Yunyi  Ma, Jinlu  Meng, Du 
Citation: Liu R, etal., Oncotarget. 2017 Oct 16;8(54):93103-93116. doi: 10.18632/oncotarget.21860. eCollection 2017 Nov 3.
RGD ID: 151347622
Pubmed: PMID:29190981   (View Abstract at PubMed)
PMCID: PMC5696247   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.21860   (Journal Full-text)

The radioresistance of hepatocellular carcinoma (HCC) cells is a critical obstacle for effectively applying radiotherapy (RT) in HCC treatment. NF-κB, an important transcription factor, can influence critical cell fate decisions by promoting cell survival or anti-apoptosis in response to cell-stress, e.g. chemotherapies or ionizing radiation (IR). A20, also named as tumor necrosis factor α induced protein 3 (TNFAIP3), is a dominant negative regulator of NF-κB pathway and its functions in HCC are largely unknown. The present work aimed to reveal the role of A20 plays in affecting the radiosensitivity of HCC cells. Higher expression of A20 was detected in hepatic non-tumor cell line or clinical specimens compared with HCC cell lines or clinical specimens. A20 decreased the expression of proteins mediating cellular stress/injury response or epithelial-mesenchymal transition (EMT) process. Overexpression of A20 via adenovirus enhanced the effect of 60Co-γ ionizing radiation (IR) on HCC cells' injury, e.g. G2/M arrest or DNA double strands break (DSB). Moreover, A20 also enhanced the in vitro or in vivo survival inhibiting of HCC cells induced by IR. These results reveal the roles of A20 in HCC radiosensitization and overexpression of A20 would be a novel strategy for HCC radiotherapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFAIP3Humanhepatocellular carcinoma  IEP mRNA:decreased expression:liver (human)RGD 
Tnfaip3Rathepatocellular carcinoma  ISOTNFAIP3 (Homo sapiens)mRNA:decreased expression:liver (human)RGD 
Tnfaip3Mousehepatocellular carcinoma  ISOTNFAIP3 (Homo sapiens)mRNA:decreased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfaip3  (TNF alpha induced protein 3)

Genes (Mus musculus)
Tnfaip3  (tumor necrosis factor, alpha-induced protein 3)

Genes (Homo sapiens)
TNFAIP3  (TNF alpha induced protein 3)


Additional Information