RGD Reference Report - Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. - Rat Genome Database

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Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.

Authors: Ungerbäck, Jonas  Belenki, Dimitri  Jawad ul-Hassan, Aksa  Fredrikson, Mats  Fransén, Karin  Elander, Nils  Verma, Deepti  Söderkvist, Peter 
Citation: Ungerbäck J, etal., Carcinogenesis. 2012 Nov;33(11):2126-34. doi: 10.1093/carcin/bgs256. Epub 2012 Jul 28.
RGD ID: 151347611
Pubmed: PMID:22843550   (View Abstract at PubMed)
DOI: DOI:10.1093/carcin/bgs256   (Journal Full-text)

Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with increased risk of colorectal cancer (CRC) development, and/or a rapidly progressing disease. In this study, 348 CRC cases and 806 randomly selected healthy individuals from southeastern Sweden were examined with regard to seven polymorphisms in NFκB pathway-associated genes. Log-rank-tests and Cox proportional hazard regression analysis examined the association between the polymorphisms and CRC-specific survival, whereas chi-square tests and logistic regression analysis were used to test for associations between the polymorphisms and CRC susceptibility. Gene expression and loss of heterozygosity analyses of TNFAIP3 were carried out in a subset of tumors to assess its role as a tumor suppressor in CRC. Heterozygous and polymorphic TNFAIP3 (rs6920220), heterozygous NLRP3 (Q705K) and polymorphic NFκB -94 ATTG ins/del genotypes were found to be associated with poorer survival in patients diagnosed with invasive CRC (aHR = 5.2, 95% CI: 2.5-10.9, P < 0.001). TNFAIP3 mRNA levels were significantly decreased in tumors compared with adjacent non-neoplastic mucosa (P < 0.0001) and loss of heterozygosity of 6q23.3 (TNFAIP3) was detected in 17% of cases, whereas only 2.5% of the investigated specimens displayed TNFAIP3 gene mutations. We propose that TNFAIP3 (rs6920220), NLRP3 (Q705K) and NFκB -94 ATTG ins/del polymorphisms are associated with poor survival in patients with advanced CRC and may be used as prognostic markers. Experimental results indicate that TNFAIP3 may act as a tumor suppressor in CRC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFAIP3Humancolorectal cancer severityIAGP DNA:SNP:3'utr: (rs6920220) (human)RGD 
Tnfaip3Ratcolorectal cancer severityISOTNFAIP3 (Homo sapiens)DNA:SNP:3'utr: (rs6920220) (human)RGD 
Tnfaip3Mousecolorectal cancer severityISOTNFAIP3 (Homo sapiens)DNA:SNP:3'utr: (rs6920220) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFAIP3HumanNeoplasm of the large intestine severityIAGP DNA:SNP:3'utr: (rs6920220) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Tnfaip3  (TNF alpha induced protein 3)

Genes (Mus musculus)
Tnfaip3  (tumor necrosis factor, alpha-induced protein 3)

Genes (Homo sapiens)
TNFAIP3  (TNF alpha induced protein 3)


Additional Information