RGD Reference Report - SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion. - Rat Genome Database

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SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion.

Authors: Chen, Ziyi  Raghoonundun, Chetnadevi  Chen, Weidong  Zhang, Yanan  Tang, Wenhao  Fan, Xin  Shi, Xin 
Citation: Chen Z, etal., Biochem Biophys Res Commun. 2018 Apr 6;498(3):579-585. doi: 10.1016/j.bbrc.2018.03.022. Epub 2018 Mar 9.
RGD ID: 150429638
Pubmed: PMID:29522714   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2018.03.022   (Journal Full-text)

SET domain containing protein 2 (SETD2, also known as HYPB) is a 230-kD protein which is located at cytogenetic band p21.31 of chromosome 3. SETD2 is usually transformed or eradicated in multiple forms of tumours in humans. However, its primary function in gastric cancer (GC) remains unclear. In the current study, we investigated the mRNA and protein expression levels of SETD2 using immunohistochemistry, qPCR, RT-PCR, and immunoblotting. The function of SETD2 in GC cells was investigated by MTT and transwell assays. Our results revealed remarkably lower levels of SETD2 mRNA and protein in the tumour samples than in tumour-adjacent tissues. Decreased expression of SETD2 mRNA was observed in 122 (79.7%) of 153 primary tumour tissue samples. On the basis of the overall survival analysis, we could interpret that a low expression of SETD2 was correlated with a poor prognosis (P < 0.001, log-rank test). Multivariate survival analysis indicated that SETD2 was an obvious prognostic factor in patients with GC. SETD2 overexpression in GC cell lines significantly inhibited cell proliferation, migration, and invasion. Altogether, the investigation demonstrated the clinical significance of SETD2 expression, supporting the fundamental principle that a decrease in its level is an unfavourable event in the progression and prognosis of GC. Therefore, down-regulated SETD2 can presumably be a potential negative prognostic and progression marker for GC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SETD2Humanstomach cancer exacerbatesIEP mRNA:decreased expression:stomach (human)RGD 
Setd2Ratstomach cancer exacerbatesISOSETD2 (Homo sapiens)mRNA:decreased expression:stomach (human)RGD 
Setd2Mousestomach cancer exacerbatesISOSETD2 (Homo sapiens)mRNA:decreased expression:stomach (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Setd2  (SET domain containing 2, histone lysine methyltransferase)

Genes (Mus musculus)
Setd2  (SET domain containing 2)

Genes (Homo sapiens)
SETD2  (SET domain containing 2, histone lysine methyltransferase)


Additional Information