RGD Reference Report - Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats.

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Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats.
Authors:	Tucker, Andrew Blake Stocker, Sean D
Citation:	Tucker AB and Stocker SD, Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R451-6. doi: 10.1152/ajpregu.00483.2015. Epub 2016 Jun 22.
RGD ID:	13792700
Pubmed:	PMID:27335281 (View Abstract at PubMed)
PMCID:	PMC5142224 (View Article at PubMed Central)
DOI:	DOI:10.1152/ajpregu.00483.2015 (Journal Full-text)
Changes in osmolality or extracellular NaCl concentrations are detected by specialized neurons in the hypothalamus to increase vasopressin (VP) and stimulate thirst. Recent in vitro evidence suggests this process is mediated by an NH2-terminal variant of the transient receptor potential vanilloid type 1 (TRPV1) channel expressed by osmosensitive neurons of the lamina terminalis and vasopressinergic neurons of the supraoptic nucleus. The present study tested this hypothesis in vivo by analysis of plasma VP levels during acute hypernatremia in awake control and TRPV1(-/-) rats. TRPV1(-/-) rats were produced by a Zinc-finger-nuclease 2-bp deletion in exon 13. Intravenous injection of the TRPV1 agonist capsaicin produced hypotension and bradycardia in control rats, but this response was absent in TRPV1(-/-) rats. Infusion of 2 M NaCl (1 ml/h iv) increased plasma osmolality, electrolytes, and VP levels in both control and TRPV1(-/-) rats. However, plasma VP levels did not differ between strains at any time. Furthermore, a linear regression between plasma VP versus osmolality revealed a significant correlation in both control and TRPV1(-/-) rats, but the slope of the regression lines was not attenuated in TRPV1(-/-) versus control rats. Hypotension produced by intravenous injection of minoxidil decreased blood pressure and increased plasma VP levels similarly in both groups. Finally, both treatments stimulated thirst; however, cumulative water intakes in response to hypernatremia or hypotension were not different between control and TRPV1(-/-) rats. These findings suggest that TRPV1 channels are not necessary for VP secretion and thirst stimulated by hypernatremia.

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Gene Ontology Annotations

Biological Process

negative regulation of heart rate (IMP)

negative regulation of systemic arterial blood pressure (IMP)

Phenotype Annotations

Mammalian Phenotype

decreased heart rate (IDA,IMP)

decreased mean systemic arterial blood pressure (IDA,IMP)

increased blood osmolality (IDA)

increased circulating antidiuretic hormone level (IDA)

increased circulating sodium level (IDA)

increased heart rate (IDA)

increased mean systemic arterial blood pressure (IDA)

Objects Annotated

Genes (Rattus norvegicus)

Trpv1 (transient receptor potential cation channel, subfamily V, member 1)

Strains

Crl:SD (NA)

SD-Trpv1^em1Sage-/- (NA)

Objects referenced in this article

Strain	SD-Trpv1^em1Sage+/+	null	Rattus norvegicus
Gene	Trpv1^em1Sage	transient receptor potential cation channel, subfamily V, member 1; ZFN induced mutant 1, Sage	Rattus norvegicus

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Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats.

Mammalian Phenotype