RGD Reference Report - EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas. - Rat Genome Database

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EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas.

Authors: Magrassi, Lorenzo  Marziliano, Nicola  Inzani, Frediano  Cassini, Pamela  Chiaranda, Ilaria  Skrap, Miran  Pizzolito, Stefano  Arienta, Cesare  Arbustini, Eloisa 
Citation: Magrassi L, etal., Cancer Lett. 2010 Apr 1;290(1):36-42. doi: 10.1016/j.canlet.2009.08.023. Epub 2009 Sep 12.
RGD ID: 13782069
Pubmed: PMID:19748727   (View Abstract at PubMed)
DOI: DOI:10.1016/j.canlet.2009.08.023   (Journal Full-text)

By qPCR we found that EDG3 and SHC3 were amplified in 60% of ependymomas but none in choroid plexus papillomas. In ependymomas EDG3 and SHC3 amplification increased Shc3 protein levels while EDG3 was less affected. Both proteins were co-immunoprecipitated from ependymoma and Shc3 was tyrosine phosphorylated thus presumably active. We showed by digestion with N-glycosidase-F that EDG3 was glycosylated indicating that EDG3 protein was not retained in the endoplasmic reticulum. The co-immunoprecipitation of Shc3 and EDG3 proteins from ependymomas with amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHC3HumanEpendymomas  IAGP DNA:amplification:brain:RGD 
Shc3RatEpendymomas  ISOSHC3 (Homo sapiens)DNA:amplification:brain:RGD 
Shc3MouseEpendymomas  ISOSHC3 (Homo sapiens)DNA:amplification:brain:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Shc3  (SHC adaptor protein 3)

Genes (Mus musculus)
Shc3  (src homology 2 domain-containing transforming protein C3)

Genes (Homo sapiens)
SHC3  (SHC adaptor protein 3)


Additional Information