RGD Reference Report - A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. - Rat Genome Database

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A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.

Authors: Tran, YK  Bogler, O  Gorse, KM  Wieland, I  Green, MR  Newsham, IF 
Citation: Tran YK, etal., Cancer Res 1999 Jan 1;59(1):35-43.
RGD ID: 1358693
Pubmed: PMID:9892180   (View Abstract at PubMed)

A novel putative tumor suppressor gene and member of the NF2/ERM/ 4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung), was shown to suppress growth. In addition, significantly reduced expression (>50%) of DAL-1 was measured in 39 primary non-small cell lung carcinoma tumors as compared with patient-matched normal lung tissue. Immunocytochemical staining with a polyclonal anti-DAL-1 antibody localized the protein to the plasma membrane, particularly at cell-cell contact points, a pattern reminiscent of other members of the protein 4.1 superfamily including ezrin and NF2. The data suggest DAL-1 is a novel membrane-associated protein with potential to play an important role in the origin and progression of lung cancer.



Gene Epb41l3 erythrocyte membrane protein band 4.1-like 3 Rattus norvegicus