RGD Reference Report - p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. - Rat Genome Database

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p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.

Authors: Stoss, O  Novoyatleva, T  Gencheva, M  Olbrich, M  Benderska, N  Stamm, S 
Citation: Stoss O, etal., Mol Cell Neurosci 2004 Sep;27(1):8-21.
RGD ID: 1358238
Pubmed: PMID:15345239   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcn.2004.04.011   (Journal Full-text)

The Sam68-like mammalian protein SLM-1 is a member of the STAR protein family and is related to SAM68 and SLM-2. Here, we demonstrate that rSLM-1 interacts with itself, scaffold-attachment factor B, YT521-B, SAM68, rSLM-2, SRp30c, and hnRNP G. rSLM-1 regulates splice site selection in vivo via a purine-rich enhancer. In contrast to the widely expressed SAM68 and rSLM-2 proteins, rSLM-1 is found primarily in brain and, to a much smaller degree, in testis. In the brain, rSLM-1 and rSLM-2 are predominantly expressed in different neurons. In the hippocampal formation, rSLM-1 is present only in the dentate gyrus, whereas rSLM-2 is found in the pyramidal cells of the CA1, CA3, and CA4 regions. rSLM-1, but not rSLM-2, is phosphorylated by p59(fyn). p59(fyn)-mediated phosphorylation abolishes the ability of rSLM-1 to regulate splice site selection, but has no effect on rSLM-2 activity. This suggests that rSLM-1-positive cells could respond with a change of their splicing pattern to p59(fyn) activation, whereas rSLM-2-positive cells would not be affected. Together, our data indicate that rSLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn).



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Khdrbs1Ratregulation of alternative mRNA splicing, via spliceosome involved_inIDA PMID:15345239UniProt 
Khdrbs3Ratregulation of alternative mRNA splicing, via spliceosome involved_inIDA PMID:15345239UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Khdrbs1Ratnucleus located_inIDA PMID:15345239UniProt 
Khdrbs3Ratnucleus located_inIDA PMID:15345239UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Khdrbs1Ratidentical protein binding enablesIPIUniProtKB:Q91V33PMID:15345239UniProt 
Khdrbs1Ratprotein binding enablesIPIUniProtKB:Q96MU7PMID:15345239UniProt 
Khdrbs1Ratprotein binding enablesIPIUniProtKB:Q15424PMID:15345239UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Khdrbs1  (KH RNA binding domain containing, signal transduction associated 1)
Khdrbs3  (KH RNA binding domain containing, signal transduction associated 3)

Objects referenced in this article
Gene Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 Rattus norvegicus

Additional Information