RGD Reference Report - The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. - Rat Genome Database

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The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative.

Authors: Hu, B  Copeland, NG  Gilbert, DJ  Jenkins, NA  Kilimann, MW 
Citation: Hu B, etal., Biochem Biophys Res Commun 2001 Aug 3;285(5):1369-76.
RGD ID: 1357924
Pubmed: PMID:11478809   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5329   (Journal Full-text)

Paralemmin is a protein implicated in plasma membrane dynamics. Here we describe the identification of two new paralemmin-related proteins. A partial paralemmin homolog, palmdelphin, is predominantly cytosolic, unlike paralemmin which is lipid-anchored to the plasma membrane through a C-terminal CaaX motif. We have mapped the mouse palmdelphin gene to distal chromosome 3 between Amy2 and Abcd3, in a region homologous to human chromosome 1p22-p21 where the human palmdelphin gene is located. We have also identified a second paralemmin isoform, paralemmin-2. It is expressed from a gene on human chromosome 9q31-q33 which ends only 33 kb upstream of the gene encoding the protein kinase A-binding protein,AKAP2/AKAP-KL. The closely adjacent paralemmin-2 and AKAP2 genes are functionally linked in a very unusual manner. Chimeric mRNAs are expressed, apparently by RNA readthrough and differential splicing, that encode natural fusion proteins in which either the N-terminal coiled-coil region or nearly the complete sequence of paralemmin-2 except its C-terminal CaaX motif is fused to AKAP2/AKAP-KL. The N-terminal coiled-coil region is conserved in paralemmin-1, paralemmin-2/AKAP2, palmdelphin and a fourth, uncharacterized gene, suggesting that it is a modular functional domain.



Objects referenced in this article
Gene Abcd3 ATP-binding cassette, sub-family D member 3 Mus musculus
Gene Pakap paralemmin A kinase anchor protein Mus musculus
Gene Palmd palmdelphin Mus musculus
Gene Palm paralemmin Rattus norvegicus

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