RGD Reference Report - Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. - Rat Genome Database

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Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis.

Authors: Rosok, O  Pedeutour, F  Ree, AH  Aasheim, HC 
Citation: Rosok O, etal., Genomics 1999 Oct 1;61(1):44-54.
RGD ID: 1357216
Pubmed: PMID:10512679   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1999.5922   (Journal Full-text)

In this study we present the cDNA sequence of a novel putative protein kinase, denoted TESK2. The open reading frame of TESK2 encodes a putative 555-amino-acid protein, including a protein kinase consensus sequence in the N-terminal half. The protein kinase domain of TESK2 is structurally similar to the kinase domain of the protein serine/threonine kinase TESK1 (64% identity) and to those of the LIMK1 and LIMK2 kinases (42 and 39% identity, respectively). TESK2, together with TESK1, constitutes a second subgroup of the LIMK/TESK family of protein kinases, as revealed by phylogenetic analysis of the protein kinase domains. Chromosomal localization of human TESK2 was assigned to 1p32. Expression analysis of human TESK2 revealed a single mRNA species of 3.0 kb predominantly expressed in testis and prostate and low expression in most other tissues examined. Rat testicles expressed a single species of TESK2 mRNA of approximately 3.5 kb. However, the transcript was first detectable in rat testis after day 30 of postnatal development and was predominantly expressed in round spermatids. These observations suggest that TESK2 plays an important role in spermatogenesis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tesk2Ratintracellular signal transduction involved_inNAS PMID:10512679UniProt 
Limk2Ratspermatid development  TAS  RGD 
Tesk2Ratspermatogenesis involved_inIEP PMID:10512679UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Limk2  (LIM domain kinase 2)
Tesk2  (testis associated actin remodelling kinase 2)


Additional Information