RGD Reference Report - Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.

Authors: Schwantes, E A  Manthei, D M  Denlinger, L C  Evans, M D  Gern, J E  Jarjour, N N  Mathur, S K 
Citation: Schwantes EA, etal., Clin Exp Allergy. 2014 Jun;44(6):813-21. doi: 10.1111/cea.12269.
RGD ID: 13506943
Pubmed: PMID:24450586   (View Abstract at PubMed)
PMCID: PMC4037351   (View Article at PubMed Central)
DOI: DOI:10.1111/cea.12269   (Journal Full-text)


BACKGROUND: The majority of asthma exacerbations are related to viral respiratory infections. Some, but not all, previous studies have reported that low interferon responses in patients with asthma increase the risk for virus-induced exacerbations.
OBJECTIVE: We sought to determine the relationship between lower airway inflammatory biomarkers, specifically interferon gene expression, and the severity or presence of an exacerbation in asthmatics experiencing a naturally occurring viral infection.
METHODS: Sputum samples were analysed from subjects in an asthma exacerbation study who experienced a confirmed viral infection. Subjects were monitored for daily symptoms, medication use and peak expiratory flow rate until baseline. Sputum samples were assessed for cell counts and gene expression.
RESULTS: Interferon gamma expression was significantly greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.002). IFN-α1, IFN-ß1 and IFN-γ mRNA levels correlated with the peak Asthma Index (r = 0.58, P < 0.001; r = 0.57, P = 0.001; and r = 0.51, P = 0.004, respectively). Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.03, P = 0.06 and P = 0.02, respectively), and IL-13 mRNA correlated with the peak Asthma Index (P = 0.006).
CONCLUSIONS: Our findings indicate that asthma exacerbations are associated with increased rather than decreased expression of interferons early in the course of infection. These findings raise the possibility that excessive virus-induced interferon production during acute infections can contribute to airway inflammation and exacerbations of asthma.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PRG2Humanasthma disease_progressionIEP associated with viral infection and mRNA:increased expression:sputum:RGD 
Prg2Ratasthma disease_progressionISOPRG2 (Homo sapiens)associated with viral infection and mRNA:increased expression:sputum:RGD 
Prg2Mouseasthma disease_progressionISOPRG2 (Homo sapiens)associated with viral infection and mRNA:increased expression:sputum:RGD 
PRG2HumanChronic Rhinosinusitis disease_progressionIEP associated with Nasal PolypsRGD 
Prg2RatChronic Rhinosinusitis disease_progressionISOPRG2 (Homo sapiens)associated with Nasal PolypsRGD 
Prg2MouseChronic Rhinosinusitis disease_progressionISOPRG2 (Homo sapiens)associated with Nasal PolypsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Prg2  (proteoglycan 2, pro eosinophil major basic protein)

Genes (Mus musculus)
Prg2  (proteoglycan 2, bone marrow)

Genes (Homo sapiens)
PRG2  (proteoglycan 2, pro eosinophil major basic protein)


Additional Information