RGD Reference Report - Syndecan-4 associates with alpha-actinin. - Rat Genome Database

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Syndecan-4 associates with alpha-actinin.

Authors: Greene, DK  Tumova, S  Couchman, JR  Woods, A 
Citation: Greene DK, etal., J Biol Chem 2003 Feb 28;278(9):7617-23. Epub 2002 Dec 18.
RGD ID: 1304266
Pubmed: PMID:12493766   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M207123200   (Journal Full-text)

Cell adhesion to the extracellular matrix influences many cellular functions. The integrin family of matrix receptors plays major roles in the formation of adhesions, but other proteins modulate integrin signaling. Syndecan-4, a transmembrane proteoglycan, cooperatively signals with integrins during the formation of focal adhesions. To date, a direct link between syndecan-4 and the cytoskeleton has remained elusive. We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Six3Ratnegative regulation of DNA-templated transcription  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Sdc4Ratfocal adhesion  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Six3Ratsignaling receptor binding  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sdc4  (syndecan 4)
Six3  (SIX homeobox 3)


Additional Information