RGD Reference Report - A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. - Rat Genome Database

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A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution.

Authors: Herrada, G  Dulac, C 
Citation: Herrada G and Dulac C, Cell 1997 Aug 22;90(4):763-73.
RGD ID: 1299420
Pubmed: PMID:9288755   (View Abstract at PubMed)

Mammals have retained two functionally and anatomically independent collections of olfactory neurons located in the main olfactory epithelium and in the vomeronasal organ (VNO). Pheromones activate the VNO in order to elicit fixed action behaviors and neuroendocrine changes involved in animal reproduction and aggression. Differential screening of cDNA libraries constructed from individual rat VNO neurons has led to the isolation of a novel family of approximately 100 genes encoding seven transmembrane receptors with sequence similarity with Ca2+-sensing and metabotropic glutamate receptors. These genes are likely to encode a novel family of pheromone receptors. Patterns of receptor gene expression suggest that the VNO is organized into discrete and sexually dimorphic functional units that may permit segregation of pheromone signals leading to specific arrays of behaviors and neuroendocrine responses.



Gene Vom2r-ps45 vomeronasal 2 receptor, pseudogene 45 Rattus norvegicus
Gene Vom2r18 vomeronasal 2 receptor, 18 Rattus norvegicus
Gene Vom2r27 vomeronasal 2 receptor, 27 Rattus norvegicus
Gene Vom2r31 vomeronasal 2 receptor, 31 Rattus norvegicus
Gene Vom2r32 vomeronasal 2 receptor, 32 Rattus norvegicus
Gene Vom2r40 vomeronasal 2 receptor, 40 Rattus norvegicus
Gene Vom2r53 vomeronasal 2 receptor, 53 Rattus norvegicus
Gene Vom2r75 vomeronasal 2 receptor, 75 Rattus norvegicus