RGD Reference Report - Somatostatin suppresses ghrelin secretion from the rat stomach. - Rat Genome Database

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Somatostatin suppresses ghrelin secretion from the rat stomach.

Authors: Shimada, M  Date, Y  Mondal, MS  Toshinai, K  Shimbara, T  Fukunaga, K  Murakami, N  Miyazato, M  Kangawa, K  Yoshimatsu, H  Matsuo, H  Nakazato, M 
Citation: Shimada M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):520-5.
RGD ID: 1299370
Pubmed: PMID:12615065   (View Abstract at PubMed)

Ghrelin is an acylated peptide that stimulates food intake and the secretion of growth hormone. While ghrelin is predominantly synthesized in a subset of endocrine cells in the oxyntic gland of the human and rat stomach, the mechanism regulating ghrelin secretion remains unknown. Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal peptides in a paracrine fashion. By double immunohistochemistry, we demonstrated that somatostatin-immunoreactive cells contact ghrelin-immunoreactive cells. A single intravenous injection of somatostatin reduced the systemic plasma concentration of ghrelin in rats. Continuous infusion of somatostatin into the gastric artery of the vascularly perfused rat stomach suppressed ghrelin secretion in both dose- and time-dependent manner. These findings indicate that ghrelin secretion from the stomach is regulated by gastric somatostatin.



Objects referenced in this article
Gene Ghrl ghrelin and obestatin prepropeptide Rattus norvegicus
Gene Sst somatostatin Rattus norvegicus

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