RGD Reference Report - Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder. - Rat Genome Database

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Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder.

Authors: Watanabe, Kentaro  Fujii, Hideki  Goto, Shunsuke  Nakai, Kentaro  Kono, Keiji  Watanabe, Shuhei  Shinohara, Masami  Nishi, Shinichi 
Citation: Watanabe K, etal., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170.
RGD ID: 12914778
Pubmed: PMID:28674323   (View Abstract at PubMed)
PMCID: PMC5827086   (View Article at PubMed Central)
DOI: DOI:10.5551/jat.40170   (Journal Full-text)


AIM: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD-MBD in a newly developed CKD rat model.
METHODS: We used male Sprague-Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes. CKD was induced by 5/6 nephrectomy (Nx). At 10 weeks, the rats were classified into six groups and administered with a vehicle or a low- or high-dose paricalcitol thrice a week. At 20 weeks, the rats were sacrificed; blood and urinary biochemical analyses and histological analysis of the aorta were performed.
RESULTS: At 20 weeks, hemoglobin A1c (HbA1c) levels, blood pressure, and renal function were not significantly different among the six groups. Serum calcium and phosphate levels tended to be higher in SDT-Nx rats than in SD-Nx rats. The urinary excretion of calcium and phosphate was significantly greater in SDT-Nx rats than in SD-Nx rats. After administering paricalcitol, serum parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) levels were significantly higher in SDT-Nx rats than in SD-Nx rats. The degree of aortic calcification was significantly more severe and the aortic calcium content was significantly greater in SDT-Nx rats than in SD-Nx rats.
CONCLUSIONS: We suggest that our new CKD rat model using SDT rats represents a useful CKD-MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Aortic Calcification inducedIAGPbilateral nephrectomy12914778 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


Objects Annotated

Strains
SD  (Sprague-Dawley)
SDT/Jcl  (NA)


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