RGD Reference Report - Interferon-mediated innate immune responses against malaria parasite liver stages. - Rat Genome Database

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Interferon-mediated innate immune responses against malaria parasite liver stages.

Authors: Miller, Jessica L  Sack, Brandon K  Baldwin, Michael  Vaughan, Ashley M  Kappe, Stefan H I 
Citation: Miller JL, etal., Cell Rep. 2014 Apr 24;7(2):436-447. doi: 10.1016/j.celrep.2014.03.018. Epub 2014 Apr 3.
RGD ID: 127345121
Pubmed: PMID:24703850   (View Abstract at PubMed)
DOI: DOI:10.1016/j.celrep.2014.03.018   (Journal Full-text)

Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by these infection-engendered innate responses. This suppression was abrogated in mice deficient in IFNγ, the type I IFN α/β receptor (IFNAR), and interferon regulatory factor 3. Natural killer and CD49b(+)CD3(+) natural killer T (NKT) cells increased in the liver after a primary infection, and CD1d-restricted NKT cells, which secrete IFNγ, were critical in reducing liver-stage burden of a secondary infection. Lack of IFNAR signaling abrogated the increase in NKT cell numbers in the liver, showing a link between type I IFN signaling, cell recruitment, and subsequent parasite elimination. Our findings demonstrate innate immune sensing of malaria parasite liver-stage infection and that the ensuing innate responses can eliminate the parasite.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
malaria exacerbatesISOCd1d1 (Mus musculus)127345121; 127345121 RGD 
malaria exacerbatesIMP 127345121 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd1d1  (CD1d1 molecule)

Genes (Mus musculus)
Cd1d1  (CD1d1 antigen)

Genes (Homo sapiens)
CD1D  (CD1d molecule)


Additional Information