RGD Reference Report - Interferon-mediated innate immune responses against malaria parasite liver stages. - Rat Genome Database

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Interferon-mediated innate immune responses against malaria parasite liver stages.

Authors: Miller, Jessica L  Sack, Brandon K  Baldwin, Michael  Vaughan, Ashley M  Kappe, Stefan H I 
Citation: Miller JL, etal., Cell Rep. 2014 Apr 24;7(2):436-447. doi: 10.1016/j.celrep.2014.03.018. Epub 2014 Apr 3.
RGD ID: 127345121
Pubmed: PMID:24703850   (View Abstract at PubMed)
DOI: DOI:10.1016/j.celrep.2014.03.018   (Journal Full-text)

Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by these infection-engendered innate responses. This suppression was abrogated in mice deficient in IFNγ, the type I IFN α/β receptor (IFNAR), and interferon regulatory factor 3. Natural killer and CD49b(+)CD3(+) natural killer T (NKT) cells increased in the liver after a primary infection, and CD1d-restricted NKT cells, which secrete IFNγ, were critical in reducing liver-stage burden of a secondary infection. Lack of IFNAR signaling abrogated the increase in NKT cell numbers in the liver, showing a link between type I IFN signaling, cell recruitment, and subsequent parasite elimination. Our findings demonstrate innate immune sensing of malaria parasite liver-stage infection and that the ensuing innate responses can eliminate the parasite.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD1DHumanmalaria exacerbatesISOCd1d1 (Mus musculus) RGD 
Cd1d1Ratmalaria exacerbatesISOCd1d1 (Mus musculus) RGD 
Cd1d1Mousemalaria exacerbatesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd1d1  (CD1d1 molecule)

Genes (Mus musculus)
Cd1d1  (CD1d1 antigen)

Genes (Homo sapiens)
CD1D  (CD1d molecule)


Additional Information