RGD Reference Report - EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population. - Rat Genome Database

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EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population.

Authors: Zhou, Yuan  Du, Wei-Dong  Wu, Qiang  Liu, Yi  Chen, Gang  Ruan, Jian  Xu, Song  Yang, Feng  Zhou, Fu-Sheng  Tang, Xian-Fa  Tang, Hua-Yang  Zuo, Xian-Bo  Zhang, Feng-Yu  Sun, Liang-Dan  Zhang, Xue-Jun 
Citation: Zhou Y, etal., Mol Carcinog. 2014 Aug;53(8):589-97. doi: 10.1002/mc.21871. Epub 2012 Jan 6.
RGD ID: 126779605
Pubmed: PMID:22228224   (View Abstract at PubMed)
DOI: DOI:10.1002/mc.21871   (Journal Full-text)

Enhancer of zeste 2 (EZH2) gene encodes a histone methyltransferase that constitutes the catalytic component of the polycomb repressive complex-2 (PRC2) to initiate epigenetic silencing of genes. It is reported that the expression level of EZH2 in gastric cancer tissue was highly correlated with tumor progression, however, whether EZH2 genetic variants were associated with the risk of gastric cancer remains yet unknown. In this study, we conducted a genotyping analysis for EZH2 in 311 cases of gastric cancer and 425 controls from the Chinese Han population. We found five single nucleotide polymorphisms (SNP; rs12670401, rs6464926, rs2072407, rs734005, and rs734004) of EZH2 gene were significantly associated with the risk of gastric cancer. Of which, the rs12670401 with the minor allele C and rs6464926 with the minor allele T revealed strong associations with increased gastric cancer risk [P = 0.009, adjusted odds ratio (aOR) = 1.327, 95% CI = 1.075-1.683 and P = 0.012, aOR = 1.310, 95% CI = 1.059-1.619]. The other three SNPs, rs2072407, rs734005, and rs734004 contributed to significantly reduced risk of gastric cancer (P = 0.033, aOR = 0.787, 95% CI = 0.633-0.981, P = 0.045, aOR = 0.799, 95% CI = 0.642-0.995 and P = 0.048, aOR = 0.803, 95% CI = 0.645-0.999), respectively. We further found that rs12670401 and rs6464926 were in a strong LD while rs2072407, rs734005, and rs734004 were in another. Haplotype analysis of the five SNPs showed that haplotype CCTCT reduced the risk of gastric cancer (P = 0.031 and aOR = 0.784), while haplotype GTCTC significantly elevated the risk of gastric cancer (P = 0.011 and aOR = 1.310). We concluded that EZH2 variants were significantly associated with gastric cancer risk. Our results for the first time provided new insight into susceptibility factors of EZH2 gene variants in carcinogenesis of gastric cancer of the Chinese Han population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EZH2Humanstomach cancer susceptibilityIAGP DNA:SNPs: :multipleRGD 
Ezh2Mousestomach cancer susceptibilityISOEZH2 (Homo sapiens)DNA:SNPs: :multipleRGD 
Ezh2Ratstomach cancer susceptibilityISOEZH2 (Homo sapiens)DNA:SNPs: :multipleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)

Genes (Mus musculus)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)

Genes (Homo sapiens)
EZH2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)


Additional Information