RGD Reference Report - EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features. - Rat Genome Database

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EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features.

Authors: Liu, Yang  Yu, Kangjie  Li, Mingyang  Zeng, Kaixuan  Wei, Jie  Li, Xia  Liu, Yixiong  Zhao, Danhui  Fan, Linni  Yu, Zhou  Wang, Yingmei  Li, Zengshan  Zhang, Wei  Bai, Qingxian  Yan, Qingguo  Guo, Ying  Wang, Zhe  Guo, Shuangping 
Citation: Liu Y, etal., Hum Pathol. 2017 Jun;64:213-221. doi: 10.1016/j.humpath.2017.04.011. Epub 2017 Apr 22.
RGD ID: 126779596
Pubmed: PMID:28438623   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humpath.2017.04.011   (Journal Full-text)

Gastrointestinal diffuse large B-cell lymphoma (GI DLBCL) is the most common gastrointestinal lymphoma. Enhancer of zeste homolog 2 (EZH2) has been implicated in the pathogenesis of several cancers. However, EZH2 has not been studied in GI DLBCL. Thus, we investigated EZH2 expression and EZH2 Y641 mutation in 100 GI DLBCL specimens by immunohistochemistry and sequencing. In addition, trimethylated H3K27 (H3K27me3), BCL2, c-MYC, and Ki-67 expression and Helicobacter pylori infection were detected, and BCL2 and c-MYC gene translocation was assessed. EZH2 was overexpressed in 50% of cases. EZH2 overexpression was significantly associated with higher stage (P = .014), higher International Prognostic Index score (P = .003), reduced overall survival rate (P = .030), and H3K27me3 (P = .001) and c-MYC expression (P = .008). We detected EZH2 mutations in 1 of 33 (3.0%) DLBCLs with a germinal center immunophenotype. The frequency of EZH2 Y641 mutation in GI DLBCL was significantly lower than that in patients with DLBCL without gastrointestinal features (P = .022). BCL2 and c-MYC translocation was detected in 6.5% and 5.1% of cases, respectively. BCL2 translocation was detected exclusively in the germinal center B-cell-like subtype. Chronic gastroenteritis was present in all cases, and 36.4% of gastric DLBCL cases had H pylori infection. The data indicate that primary GI DLBCL is closely related with chronic inflammation and has a low frequency of molecular abnormality, and EZH2 overexpression is significantly associated with inferior outcome in patients with primary GI DLBCL; evaluating EZH2 expression has therapeutic implications.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EZH2Humandiffuse large B-cell lymphoma  IEP  RGD 
Ezh2Mousediffuse large B-cell lymphoma  ISOEZH2 (Homo sapiens) RGD 
Ezh2Ratdiffuse large B-cell lymphoma  ISOEZH2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)

Genes (Mus musculus)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)

Genes (Homo sapiens)
EZH2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)


Additional Information