RGD Reference Report - Associations Between Loss of ARID1A Expression and Clinicopathologic and Genetic Variables in T1 Early Colorectal Cancer. - Rat Genome Database

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Associations Between Loss of ARID1A Expression and Clinicopathologic and Genetic Variables in T1 Early Colorectal Cancer.

Authors: Kishida, Yoshihiro  Oishi, Takuma  Sugino, Takashi  Shiomi, Akio  Urakami, Kenichi  Kusuhara, Masatoshi  Yamaguchi, Ken  Kitagawa, Yuko  Ono, Hiroyuki 
Citation: Kishida Y, etal., Am J Clin Pathol. 2019 Sep 9;152(4):463-470. doi: 10.1093/ajcp/aqz062.
RGD ID: 126777686
Pubmed: PMID:31263894   (View Abstract at PubMed)
DOI: DOI:10.1093/ajcp/aqz062   (Journal Full-text)


OBJECTIVES: To evaluate the relationships between adenine-thymine-rich interactive domain 1A (ARID1A) expression and the clinicopathologic features in T1 colorectal cancer (CRC) and to investigate whether the presence of ARID1A protein is related to genetic changes.
METHODS: We retrospectively studied 219 surgically resected T1 CRCs. ARID1A expression was assessed by immunohistochemical methods, and the correlation between ARID1A expression and clinicopathologic features was evaluated. The relationship between ARID1A expression and 409 cancer-related gene mutations was also evaluated using next-generation sequencing (NGS).
RESULTS: Immunohistochemical staining indicated negative ARID1A expression in 4.6%. Loss of ARID1A expression was significantly associated with younger age, lymphatic invasion, and lymph node metastasis (LNM). NGS showed that PKHD1, RNF213, and MSH6 mutations were more frequent in ARID1A-negative tumors, whereas KRAS mutations were more common in ARID1A-positive tumors.
CONCLUSIONS: In T1 CRC, negative ARID1A expression was correlated with early onset, lymphatic invasion, and LNM. Mutations in some cancer-related genes were possibly related with ARID1A expression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ARID1AHumancolorectal cancer exacerbatesIEP protein:decreased expression:colorectum (human)RGD 
Arid1aRatcolorectal cancer exacerbatesISOARID1A (Homo sapiens)protein:decreased expression:colorectum (human)RGD 
Arid1aMousecolorectal cancer exacerbatesISOARID1A (Homo sapiens)protein:decreased expression:colorectum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Arid1a  (AT-rich interaction domain 1A)

Genes (Mus musculus)
Arid1a  (AT-rich interaction domain 1A)

Genes (Homo sapiens)
ARID1A  (AT-rich interaction domain 1A)


Additional Information