RGD Reference Report - Differential subcellular localization of Ror tyrosine kinase receptors in cultured astrocytes. - Rat Genome Database

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Differential subcellular localization of Ror tyrosine kinase receptors in cultured astrocytes.

Authors: Paganoni, S  Anderson, KL  Ferreira, A 
Citation: Paganoni S, etal., Glia. 2004 May;46(4):456-66.
RGD ID: 11537371
Pubmed: PMID:15095375   (View Abstract at PubMed)
DOI: DOI:10.1002/glia.20023   (Journal Full-text)

Ror1 and Ror2 belong to a family of tyrosine kinase receptors that are highly conserved among species. They are expressed throughout the organism, including the central nervous system. In the present study, we analyzed the expression and subcellular localization of Ror1 and Ror2 in astrocytes by means of reverse transcription-polymerase chain reaction, Western blot analysis, and immunocytochemistry. Our results indicated that both Ror1 and Ror2 are readily detectable in cultured astrocytes. They also showed that Ror1 and Ror2 are associated with different components of the cytoskeleton. While Ror1 co-localized with F-actin along stress fibers, Ror2 partially co-localized with microtubules. In addition, our results suggest that Ror1 and Ror2 undergo different posttranslational modifications in cultured astrocytes. Ror1 is highly glycosylated in these cells. In contrast, no glycosylation was detected in Ror2. Taken together, these results suggest distinct roles for these tyrosine kinase receptors in astrocytes.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Ror1Ratastrocyte development  IDA  RGD 
Ror2Ratastrocyte development  IDA  RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Ror1Ratcell surface  IDA  RGD 
Ror2Ratcell surface  IDA  RGD 
Ror2Ratmicrotubule  IDA  RGD 
Ror1Ratstress fiber  IDA  RGD 


Genes (Rattus norvegicus)
Ror1  (receptor tyrosine kinase-like orphan receptor 1) Ror2  (receptor tyrosine kinase-like orphan receptor 2)