RGD Reference Report - The involvement of Type II Neuregulin-1 in rat visuospatial learning and memory. - Rat Genome Database

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The involvement of Type II Neuregulin-1 in rat visuospatial learning and memory.

Authors: Taylor, AR  Taylor, SB  Koenig, JI 
Citation: Taylor AR, etal., Neurosci Lett. 2012 Dec 7;531(2):131-5. doi: 10.1016/j.neulet.2012.10.018. Epub 2012 Oct 23.
RGD ID: 10449010
Pubmed: PMID:23098760   (View Abstract at PubMed)
PMCID: PMC3517732   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neulet.2012.10.018   (Journal Full-text)

The cognitive deficits observed in schizophrenia are considered a core feature of the disease. Neuregulin-1 is a risk gene for schizophrenia that is involved in many neurodevelopmental and synaptic plasticity-related processes relevant to schizophrenia. Here, we have utilized a rat model (Nrg1(Tn)), which is hypomorphic for the neuregulin-1 (Nrg1) gene, to test whether reduced Type II NRG1 in the rat brain leads to cognitive deficits relevant to schizophrenia. Wild-type and homozygous Nrg1(Tn) male rats were tested in memory tasks that evaluated spatial memory (Morris water maze) and visuospatial working and reference memory (Can Test). Nrg1(Tn) rats were not impaired on the Morris water maze, but did show a deficit in the appetitive visuospatial discrimination test. Nrg1(Tn) rats committed more reference and working memory errors in this test. These results indicate that decreased Type II NRG1 in the brain may lead to deficits in visuospatial learning and memory.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
memory  IMP 10449010 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal spatial reference memory  IMP 10449010DNA:transposon insertionRGD 
abnormal spatial working memory  IMP 10449010DNA:transposon insertionRGD 
Objects Annotated

Genes (Rattus norvegicus)
Nrg1  (neuregulin 1)


Additional Information