RGD Reference Report - Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. - Rat Genome Database

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Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis.

Authors: Knoch, KP  Bergert, H  Borgonovo, B  Saeger, HD  Altkruger, A  Verkade, P  Solimena, M 
Citation: Knoch KP, etal., Nat Cell Biol. 2004 Mar;6(3):207-14. Epub 2004 Feb 22.
RGD ID: 10045958
Pubmed: PMID:15039777   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb1099   (Journal Full-text)

Pancreatic beta-cells store insulin in secretory granules that undergo exocytosis upon glucose stimulation. Sustained stimulation depletes beta-cells of their granule pool, which must be quickly restored. However, the factors promoting rapid granule biogenesis are unknown. Here we show that beta-cell stimulation induces the nucleocytoplasmic translocation of polypyrimidine tract-binding protein (PTB). Activated cytosolic PTB binds and stabilizes mRNAs encoding proteins of secretory granules, thus increasing their translation, whereas knockdown of PTB expression by RNA interference (RNAi) results in the depletion of secretory granules. These findings may provide insight for the understanding and treatment of diabetes, in which insulin secretion is typically impaired.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ptbp1Ratnuclear-transcribed mRNA catabolic process  IMP  RGD 
Ptbp1Ratpositive regulation of insulin secretion  IMP  RGD 
Ptbp1Ratpositive regulation of secretory granule organization  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptbp1  (polypyrimidine tract binding protein 1)


Additional Information