GWAS1260395_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1260395_H (hypothyroidism QTL GWAS1260395 (human)) Homo sapiens

Symbol: GWAS1260395_H
Name: hypothyroidism QTL GWAS1260395 (human)
RGD ID: 597164321
Trait: hypothyroidism
LOD Score: Not Available
P Value: 2.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381236,465,834 - 236,465,835RGD_MAPPER_PIPELINEGRCh38
GRCh371236,629,134 - 236,629,135RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1260395_HHumanhypothyroidism  IAGPrs12117927405850206 GWAS_CATALOGPMID:34594039

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1260395_HHumanHypothyroidism  IAGPrs12117927405850206 GWAS_CATALOGPMID:34594039
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1260395_HHumanhypothyroidism  IAGPrs12117927405850206 GWAS_CATALOGPMID:34594039

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1351297EDARADDEDAR associated via death domain1236348259236484930Human


Peak: (rs12117927)
Human AssemblyChrPosition (strand)Source
GRCh381236,465,834 - 236,465,835RGD_MAPPER_PIPELINE


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597279886GWAS1375960_Hhypothyroidism QTL GWAS1375960 (human)1e-10hypothyroidism1236465834236465835Human
597081966GWAS1178040_Hautoimmune thyroid disease QTL GWAS1178040 (human)2e-11autoimmune thyroid disease1236465834236465835Human
597278672GWAS1374746_Hhypothyroidism QTL GWAS1374746 (human)1e-11hypothyroidism1236465834236465835Human
597164321GWAS1260395_Hhypothyroidism QTL GWAS1260395 (human)2e-09hypothyroidism1236465834236465835Human
596979848GWAS1099367_Hhypothyroidism QTL GWAS1099367 (human)1e-10hypothyroidism1236465834236465835Human
597060216GWAS1156290_Hhypothyroidism QTL GWAS1156290 (human)4e-09hypothyroidism1236465834236465835Human



Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1260395_H GCST90018862 Hypothyroidism 30,155 European ancestry cases, 379,986 European ancestry controls, 1,114 East Asian ancestry cases, 172,656 East Asian ancestry controls A NR 2E-9 8.699 rs12117927 0.0627 hypothyroidism (EFO:0004705)
 PMID:34594039
GWAS1156290_H GCST007073 Hypothyroidism approximately 459,000 European ancestry individuals ? NR 4E-9 8.398 rs12117927 N/A hypothyroidism (EFO:0004705)
 PMID:30595370
GWAS1178040_H GCST010571 Autoimmune thyroid disease 30,234 European ancestry cases, 724,172 European ancestry controls A 0.484 2E-11 10.699 rs12117927 1.06 autoimmune thyroid disease (EFO:0006812)
 PMID:32581359
GWAS1374746_H GCST90204167 Hypothyroidism 51,194 European ancestry cases, 443,383 European ancestry controls A NR 1E-11 11 rs12117927 0.0558823 hypothyroidism (EFO:0004705)
 PMID:36093044
GWAS1375960_H GCST90319320 Hypothyroidism 58,783 European ancestry cases, 633,203 European ancestry controls A NR 1E-10 10 rs12117927 1.05 hypothyroidism (EFO:0004705)
 PMID:39067062
Database
Acc Id
Source(s)
GWAS Catalog GCST90018862 GWAS Catalog

Note Type Note Reference