GWAS1011469_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1011469_H (Agents acting on the renin-angiotensin system use measurement QTL GWAS1011469 (human)) Homo sapiens

Symbol: GWAS1011469_H
Name: Agents acting on the renin-angiotensin system use measurement QTL GWAS1011469 (human)
RGD ID: 407362493
Trait: Agents acting on the renin-angiotensin system use measurement
LOD Score: Not Available
P Value: 2.0E-8
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38314,853,598 - 14,853,599RGD_MAPPER_PIPELINEGRCh38
GRCh37314,895,105 - 14,895,106RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1011469_HHumanAgents acting on the renin-angiotensin system use measurement  IAGPrs4684242405850206 GWAS_CATALOGPMID:34594039
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1313708FGD5FYVE, RhoGEF and PH domain containing 531481068814934571Human

Position Markers

Peak: (rs4684242)
Human AssemblyChrPosition (strand)Source
GRCh38314,853,598 - 14,853,599RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407079362GWAS728338_Hmean arterial pressure QTL GWAS728338 (human)2e-12mean arterial pressuremean arterial blood pressure (CMO:0000009)31485359814853599Human
407067300GWAS716276_Hsystolic blood pressure QTL GWAS716276 (human)3e-11systolic blood pressuresystolic blood pressure (CMO:0000004)31485359814853599Human
407167790GWAS816766_Hdiastolic blood pressure QTL GWAS816766 (human)5e-10diastolic blood pressurediastolic blood pressure (CMO:0000005)31485359814853599Human
407084904GWAS733880_Hdiastolic blood pressure QTL GWAS733880 (human)6e-10diastolic blood pressurediastolic blood pressure (CMO:0000005)31485359814853599Human
407070606GWAS719582_Hdiastolic blood pressure QTL GWAS719582 (human)8e-11diastolic blood pressurediastolic blood pressure (CMO:0000005)31485359814853599Human
407085774GWAS734750_Hsystolic blood pressure QTL GWAS734750 (human)1e-10systolic blood pressuresystolic blood pressure (CMO:0000004)31485359814853599Human
407185845GWAS834821_Hmean arterial pressure QTL GWAS834821 (human)1e-12mean arterial pressuremean arterial blood pressure (CMO:0000009)31485359814853599Human
407084016GWAS732992_Hmean arterial pressure QTL GWAS732992 (human)6e-12mean arterial pressuremean arterial blood pressure (CMO:0000009)31485359814853599Human
407187762GWAS836738_Hsystolic blood pressure QTL GWAS836738 (human)1e-11systolic blood pressuresystolic blood pressure (CMO:0000004)31485359814853599Human
407073562GWAS722538_Hhypertension QTL GWAS722538 (human)2e-11hypertension31485359814853599Human
2316345GLUCO224_HGlucose level QTL 224 (human)1.270.008Glucose level3121543441Human
407362493GWAS1011469_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1011469 (human)2e-08Agents acting on the renin-angiotensin system use measurement31485359814853599Human
407361787GWAS1010763_HBeta blocking agent use measurement QTL GWAS1010763 (human)3e-08Beta blocking agent use measurement31485359814853599Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS716276_H GCST007703 Systolic blood pressure 130,777 Japanese ancestry individuals C 0.35 3E-11 10.523 rs4684242 0.5196 systolic blood pressure (EFO:0006335)
 PMID:30487518
GWAS719582_H GCST007704 Diastolic blood pressure 130,777 Japanese ancestry individuals C 0.3541 8E-11 10.097 rs4684242 0.3241 diastolic blood pressure (EFO:0006336)
 PMID:30487518
GWAS722538_H GCST007707 Hypertension 22,566 Japanese ancestry cases, 28,226 Japanese ancestry controls C 0.3541 2E-11 10.699 rs4684242 0.0935 hypertension (EFO:0000537)
 PMID:30487518
GWAS728338_H GCST007706 Mean arterial pressure 130,777 Japanese ancestry individuals C 0.3541 2E-12 11.699 rs4684242 0.39 mean arterial pressure (EFO:0006340)
 PMID:30487518
GWAS732992_H GCST006010 Mean arterial pressure 136,482 Japanese ancestry individuals ? NR 6E-12 11.222 rs4684242 0.02744 mean arterial pressure (EFO:0006340)
 PMID:29403010
GWAS733880_H GCST005978 Diastolic blood pressure 136,615 Japanese ancestry individuals ? NR 6E-10 9.222 rs4684242 0.02449 diastolic blood pressure (EFO:0006336)
 PMID:29403010
GWAS734750_H GCST005979 Systolic blood pressure 136,597 Japanese ancestry individuals ? NR 1E-10 10 rs4684242 0.02556 systolic blood pressure (EFO:0006335)
 PMID:29403010
GWAS816766_H GCST90018732 Diastolic blood pressure 145,515 East Asian ancestry individuals C 0.353439 5E-10 9.302 rs4684242 0.0226488 diastolic blood pressure (EFO:0006336)
 PMID:34594039
GWAS834821_H GCST90018743 Mean arterial pressure 145,502 East Asian ancestry individuals C 0.35344 1E-12 12 rs4684242 0.0253358 mean arterial pressure (EFO:0006340)
 PMID:34594039
GWAS836738_H GCST90018752 Systolic blood pressure 145,505 East Asian ancestry individuals C 0.353439 1E-11 11 rs4684242 0.0236988 systolic blood pressure (EFO:0006335)
 PMID:34594039
GWAS1010763_H GCST90018986 Medication use (beta blocking agents) 31,700 European ancestry cases, 192,324 European ancestry controls, 20,367 East Asian ancestry cases, 158,359 East Asian ancestry controls C NR 3E-8 7.523 rs4684242 0.0437 Beta blocking agent use measurement (EFO:0009929)
 PMID:34594039
GWAS1011469_H GCST90018988 Medication use (agents acting on the renin-angiotensin system) 62,752 European ancestry cases, 174,778 European ancestry controls, 45,820 East Asian ancestry cases, 132,906 East Asian ancestry controls C NR 2E-8 7.699 rs4684242 0.0331 Agents acting on the renin-angiotensin system use measurement (EFO:0009931)
 PMID:34594039
Database Acc Id Source(s)
GWAS Catalog GCST90018988 GWAS Catalog

RGD Curation Notes
Note Type Note Reference