GWAS847133_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS847133_H (non-alcoholic fatty liver disease QTL GWAS847133 (human)) Homo sapiens

Symbol: GWAS847133_H
Name: non-alcoholic fatty liver disease QTL GWAS847133 (human)
RGD ID: 407198157
Trait: non-alcoholic fatty liver disease
LOD Score: Not Available
P Value: 4.0E-10
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38312,225,355 - 12,225,356RGD_MAPPER_PIPELINEGRCh38
GRCh37312,266,855 - 12,266,856RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs1584063)
Human AssemblyChrPosition (strand)Source
GRCh38312,225,355 - 12,225,356RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407278086GWAS927062_Hlow density lipoprotein cholesterol measurement QTL GWAS927062 (human)2e-09low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)31222535512225356Human
407155287GWAS804263_Hlow density lipoprotein cholesterol measurement, alcohol drinking QTL GWAS804263 (human)7e-14low density lipoprotein cholesterol measurement, alcohol drinkingblood low density lipoprotein cholesterol level (CMO:0000053)31222535512225356Human
407160192GWAS809168_Hlow density lipoprotein cholesterol measurement QTL GWAS809168 (human)0.000002low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)31222535512225356Human
407204017GWAS852993_Hmonocyte count QTL GWAS852993 (human)5e-45monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)31222535512225356Human
407198157GWAS847133_Hnon-alcoholic fatty liver disease QTL GWAS847133 (human)4e-10non-alcoholic fatty liver disease31222535512225356Human
407155565GWAS804541_Hlow density lipoprotein cholesterol measurement, alcohol consumption measurement QTL GWAS804541 (human)4e-09low density lipoprotein cholesterol measurement, alcohol consumption measurementethanol drink intake rate (CMO:0001407)31222535512225356Human
2316345GLUCO224_HGlucose level QTL 224 (human)1.270.008Glucose level3121543441Human
407155768GWAS804744_Hlow density lipoprotein cholesterol measurement, alcohol drinking QTL GWAS804744 (human)8e-10low density lipoprotein cholesterol measurement, alcohol drinkingblood low density lipoprotein cholesterol level (CMO:0000053)31222535512225356Human
407291594GWAS940570_Htotal cholesterol measurement QTL GWAS940570 (human)6e-67total cholesterol measurementblood total cholesterol level (CMO:0000051)31222535512225356Human
407158937GWAS807913_Hlow density lipoprotein cholesterol measurement, alcohol consumption measurement QTL GWAS807913 (human)1e-13low density lipoprotein cholesterol measurement, alcohol consumption measurementethanol drink intake rate (CMO:0001407)31222535512225356Human
407153689GWAS802665_Hlow density lipoprotein cholesterol measurement QTL GWAS802665 (human)5e-10low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)31222535512225356Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
None Available GCST90309369 Neutrophils and lymphocytes in blood (confirmatory factor analysis Factor 35) 349,613 European ancestry individuals ? NR 7E-18 17.155 rs1584063 N/A lymphocyte measurement (EFO:0803546)
neutrophil measurement (EFO:0803548)
 PMID:38965376
GWAS802665_H GCST008077 LDL cholesterol levels 89,893 European ancestry individuals, 20,989 African American individuals, 12,450 Asian ancestry individuals, 3,994 HIspanic individuals A NR 5E-10 9.302 rs1584063 1.056 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:30698716
GWAS804263_H GCST008079 LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) 56,505 European ancestry current drinkers, 9,870 African American current drinkers, 2,491 Asian ancestry current drinkers, 2,528 Hispanic current drinkers, 33,388 European ancestry non-drinkers, 11,119 African American non-drinkers, 9,959 Asian ancestry non-drinkers, 1,466 Hispanic non-drinkers A NR 7E-14 13.155 rs1584063 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
alcohol drinking (EFO:0004329)
 PMID:30698716
GWAS804541_H GCST008078 LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) 44,831 European ancestry regular drinkers, 3,976 African American regular drinkers, 1,288 Asian ancestry regular drinkers, 827 Hispanic regular drinkers, 11,674 European ancestry non-regular drinkers, 5,894 African American non-regular drinkers, 1,203 Asian ancestry non-regular drinkers, 1,701 Hispanic non-regular drinkers A NR 4E-9 8.398 rs1584063 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
alcohol consumption measurement (EFO:0007878)
 PMID:30698716
GWAS804744_H GCST008079 LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) 56,505 European ancestry current drinkers, 9,870 African American current drinkers, 2,491 Asian ancestry current drinkers, 2,528 Hispanic current drinkers, 33,388 European ancestry non-drinkers, 11,119 African American non-drinkers, 9,959 Asian ancestry non-drinkers, 1,466 Hispanic non-drinkers A NR 8E-10 9.097 rs1584063 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
alcohol drinking (EFO:0004329)
 PMID:30698716
GWAS807913_H GCST008078 LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) 44,831 European ancestry regular drinkers, 3,976 African American regular drinkers, 1,288 Asian ancestry regular drinkers, 827 Hispanic regular drinkers, 11,674 European ancestry non-regular drinkers, 5,894 African American non-regular drinkers, 1,203 Asian ancestry non-regular drinkers, 1,701 Hispanic non-regular drinkers A NR 1E-13 13 rs1584063 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
alcohol consumption measurement (EFO:0007878)
 PMID:30698716
GWAS809168_H GCST008077 LDL cholesterol levels 89,893 European ancestry individuals, 20,989 African American individuals, 12,450 Asian ancestry individuals, 3,994 HIspanic individuals A NR 0.000002 5.699 rs1584063 1.116 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:30698716
GWAS847133_H GCST90094908 Nonalcoholic fatty liver disease (imputed) 28,396 European ancestry cases, 108,652 European ancestry controls ? NR 4E-10 9.398 rs1584063 0.00571137 non-alcoholic fatty liver disease (EFO:0003095)
 PMID:35047847
GWAS852993_H GCST90002393 Monocyte count 408,112 British individuals A 0.456363 5E-45 44.302 rs1584063 0.03122586 monocyte count (EFO:0005091)
 PMID:32888494
None Available GCST90435195 Thyroid stimulating hormone levels within normal range in pregnancy 67,471 Chinese ancestry individuals A 0.40561 1E-11 11 rs1584063 0.0461 thyroid stimulating hormone measurement (EFO:0004748)
 PMID:39266554
GWAS927062_H GCST008086 LDL cholesterol levels in current drinkers 56,505 European ancestry individuals, 9,870 African American individuals, 2,491 Asian ancestry individuals, 2,528 Hispanic individuals A NR 2E-9 8.699 rs1584063 0.883 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:30698716
GWAS940570_H GCST90239673 Total cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 6E-67 66.222 rs1584063 N/A total cholesterol measurement (EFO:0004574)
 PMID:34887591
Database Acc Id Source(s)
GWAS Catalog GCST90094908 GWAS Catalog

RGD Curation Notes
Note Type Note Reference